Synthesis of deuterium-labeled androst-5-ene-17β,19-diol and its 4-ene isomer as internal standards for the determination of the 19-oxygenation of aromatase inhibitors using GC-MS

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 2, 1999, Pages 263-266

  Nagaoka, Masao ^a   Morio, Makoto ^a   Numazawa, Mitsuteru ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

19 oxygenation; Aromatase inhibitor; Deuterium labeled steroid; GC MS; Internal standard; Synthesis

Indexed keywords

ANDROST 4 ENE 17BETA,19 DIOL[3,3,7,7,DEUTERIUM]; ANDROST 5 ENE 17BETA,19 DIOL[3BETA,7,7.17ALPHA DEUTERIUM]; AROMATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; COMPETITIVE INHIBITION; DRUG CONFORMATION; DRUG HYDROXYLATION; DRUG SYNTHESIS; ENZYME INHIBITION; ESTROGEN SYNTHESIS; GAS CHROMATOGRAPHY; HORMONAL REGULATION; MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION;

EID: 0032942888     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.263     Document Type: Article

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