Binding of the active metabolite of chloral hydrate, 2,2,2-trichloroethanol, to serum albumin demonstrated using tryptophan fluorescence quenching

Pharmacology

Volumn 64, Issue 3, 2002, Pages 152-159

  Solt, Ken ^a   Johansson, Jonas S ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Albumin; Anesthetic mechanisms; Anesthetic protein interaction; Chloral hydrate; Fluorescence; Trichloroethanol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALBUMINOID; ALCOHOL; BOVINE SERUM ALBUMIN; CHLORAL HYDRATE; CHLOROFORM; DRUG METABOLITE; HALOTHANE; HUMAN ALBUMIN; ION; ION CHANNEL; LIGAND; SEROTONIN 3 RECEPTOR; TRICHLOROETHANOL; TRYPTOPHAN;

ALBUMIN BLOOD LEVEL; ALPHA HELIX; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; FLUORESCENCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; STEADY STATE; STRUCTURE ANALYSIS;

ANIMALS; CATTLE; CHLORAL HYDRATE; CIRCULAR DICHROISM; ETHYLENE CHLOROHYDRIN; HUMANS; HYPNOTICS AND SEDATIVES; PROTEIN BINDING; PROTEIN CONFORMATION; SERUM ALBUMIN; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 0036166637     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056165     Document Type: Article

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