Trichloroethanol impairs NMDA receptor function in rat mesencephalic and cortical neurones

European Journal of Pharmacology

Volumn 366, Issue 2-3, 1999, Pages R1-

  Scheibler, Peter ^a   Kronfeld, Anita ^a   Illes, Peter ^a   Allgaier, Clemens ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

2,2,2 Trichloroethanol; Ca2+ concentration; Intracellular; NMDA receptor

Indexed keywords

CHLORAL HYDRATE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRICHLOROETHANOL;

ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN CORTEX; CALCIUM METABOLISM; CONTROLLED STUDY; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; SHORT SURVEY;

EID: 0033042157     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00924-8     Document Type: Article

References (8)

1. Breimer D.D. Clinical pharmacokinetics of hypnotics. Clin. Pharmacokinet. 2:1977;93-109.
2. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
3. Hansson, E., Rönnbäck, L., 1989. Primary cultures of astroglia and neurons from different brain regions. In: Shahar, A., de Vellis, J., Vernadakis, A., Haber, B. (Eds.), A Dissection and Tissue Culture Manual of the Nervous System. Wiley-Liss, New York, NY, pp. 92-104.
4. A receptors in hippocampal neurons. J. Pharmacol. Exp. Ther. 264:1993;1097-1103.
5. Owen B.E., Taverner P.V. Studies on the hypnotic effects of chloral hydrate and ethanol and their metabolism in vivo and in vitro. Biochem. Pharmacol. 29:1980;3011-3016.
6. Peoples R.W., Weight F.F. Inhibition of excitatory amino acid-activated currents by trichloroethanol and trifluoroethanol in mouse hippocampal neurones. Br. J. Pharmacol. 124:1998;1159-1164.
7. Scheibler P., Müller D., Richter M., Illes P., Allgaier C. NMDA receptor characterisation of rat cultured mesencephalic neurones. Naunyn-Schmiedeberg's Arch. Pharmacol. 357:1998;R97.
8. Shimoda K., Sauve Y., Marini A., Schwartz J.P., Commissiong J.W. A high percentage yield of tyrosine hydroxylase-positive cells from rat E14 mesencephalic cell culture. Brain Res. 586:1992;319-331.