Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit endothelium-dependent arterial relaxation

Journal of Lipid Research

Volumn 43, Issue 1, 2002, Pages 158-166

  Kamido, Hiroshi ^a,c   Eguchi, Hiroyuki ^a   Ikeda, Hisao ^a   Imaizumi, Tsutomu ^a   Yamana, Kazunari ^a,d   Hartvigsen, Karsten ^b   Ravandi, Amir ^b   Kuksis, Arnis ^b  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TORONTO   (Canada)

^c Midori Health Care Foundation   (Japan)

^d Sugi Hospital   (Japan)

Author keywords

Acute coronary syndrome; Glycerophosphocholine; Lipid peroxidation; Mass spectrometry; Phospholipid; Platelet activating factor

Indexed keywords

1 O HEXADECYL 2 (5 OXOVALEROYL)GLYCEROPHOSPHOCHOLINE; 1 O HEXADECYL 2 ACETYLGLYCEROPHOSPHOCHOLINE; 1 PALMITOYL 2 ACETYLGLYCEROPHOSPHOCHOLINE; ALDEHYDE DERIVATIVE; ALKYL GROUP; GLYCEROPHOSPHORYLCHOLINE; PHOSPHOLIPID; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE SHAPE; VASCULAR ENDOTHELIUM; VASODILATATION;

ADULT; AGED; ALDEHYDES; ARTERIES; ARTERIOSCLEROSIS; BLOOD PLATELETS; CELL SIZE; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; LIPID PEROXIDATION; MALE; MIDDLE AGED; PHOSPHATIDYLCHOLINES; PHOSPHOLIPID ETHERS; PLATELET AGGREGATION; REFERENCE STANDARDS; VASODILATION;

EID: 0036163895     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics
2. Coronary plaque disruption
3. Molecular bases of the acute coronary syndromes
4. Relation of plaque lipid composition and morphology to the stability of human aortic plaques
5. Lipid esterbound aldehydes among copper-catalyzed peroxidation products of human plasma lipoproteins
6. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
7. Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions
8. Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis: In vitro and in vivo inhibition by WEB 2086
9. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines
10. Molecular species of glycerophospholipids and sphingomyelins of human plasma: Comparison to red blood cells
11. Different fatty chain compositions of alkenylacyl, alkylacyl and diacyl phospholipids in rabbit alveolar macrophages: High amounts of arachidonic acid in ether phospholipids
12. Identification of core aldehydes among in vitro peroxidation products of cholesteryl esters
13. Determination of lipid ester ozonides and core aldehydes by high-performance liquid chromatography with on-line mass spectrometry
14. Autoxidation of human low density, lipoprotein: Loss of polyunsaturated fatty acids and vitaminE and generation of aldehydes
15. Isolation and identification of glycated aminophospholipids from red cells and plasma of diabetic blood
16. Glycated phosphatidylethanolamine promotes macrophage uptake of low density lipoprotein and accumulation of cholesteryl esters and triacylglycerols
17. Protein kinase C inhibitors suppress disc-sphere changes of human platelets, as assessed with the shape-change parameter
18. Functional morphological alterations of human blood plateletes induced by oxidized low density lipoprotein
19. x
20. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators)
21. Structural analogs of platelet-activating factor (PAF-acether)
22. Platelet-aggregating effects of platelet-activating factor-like phospholipids formed by oxidation of phosphatidylcholines containing an sn-2-polyunsaturated fatty acyl group
23. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways
24. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta
25. Membrane active lipids in remnant lipoproteins cause impairment of endothelium-dependent vasorelaxation
26. Analysis of phospholipids of plasma lipoproteins, red blood cells and atheroma
27. Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
28. Biologically active oxidized phospholipids
29. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and nentrophils
30. Determinants of bioactivity of oxidized phospholipids: Specific oxidized fatty acyl groups at the sn-2 position
31. Oxidation-specific epitopes in human coronary atherosclerosis are not limited to oxidized low-density lipoprotein
32. Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions
33. Modified phosphatidylethanolamine as the active component of oxidized low density lipoprotein promoting platelet prothrombinase activity
34. Angioscopic evaluation of coronary-artery thrombi in acute coronary syndromes
35. Measurement of platelet-activating factor in a canine model coronary thrombosis and in endarterectomy samples from patients with advanced coronary artery disease