Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat

Medical Science Monitor

Volumn 8, Issue 1, 2002, Pages

  Bianca, Roberta D'Emmanuele ^a,c   Wayman, Nicole S ^a   McDonald, Michelle C ^a   Pinto, Aldo ^c   Sharpe, Martyn A ^b   Chatterjee, Prabal K ^a   Thiemermann, Christoph ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Department of Experimental Pharmacology ^*  (Italy)

Author keywords

EUK 134; EUK 8; Multiple organ failure; Oxygen radicals; Shock; Superoxide anions; Superoxide dismutase

Indexed keywords

CATALASE; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTRAVAL SODIUM; MANGANESE DERIVATIVE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; BOLUS INJECTION; CONTROLLED STUDY; DRUG EFFECT; ENDOTOXEMIA; ENZYME ACTIVITY; HEMODYNAMIC MONITORING; HYPOTENSION; KIDNEY INJURY; LIVER INJURY; MALE; MULTIPLE ORGAN FAILURE; MUSCLE INJURY; NONHUMAN; PANCREAS INJURY; RAT; SEPTIC SHOCK; STATISTICAL ANALYSIS;

ANIMALS; ENDOTOXINS; HYPOTENSION; KIDNEY; LIVER; MALE; MANGANESE COMPOUNDS; MUSCLE, SKELETAL; ORGANOMETALLIC COMPOUNDS; PANCREAS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SALICYLATES; SHOCK, SEPTIC; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 0036163029     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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