Low CD7 expression in benign and malignant cutaneous lymphocytic infiltrates: Experience with an antibody reactive with paraffin-embedded tissue

American Journal of Dermatopathology

Volumn 24, Issue 1, 2002, Pages 6-16

  Murphy, Michael ^a   Fullen, Doug ^a   Carlson, J Andrew ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

CD7; Cutaneous T cell lymphoma; Lichenoid dermatitis; Lymphocytic infiltrates; Mycosis fungoides; Paraffin embedded; Parapsoriasis; Spongiotic dermatitis

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; PARAFFIN;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BENIGN TUMOR; CLINICAL ARTICLE; CONTROLLED STUDY; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LOGISTIC REGRESSION ANALYSIS; LYMPHOCYTIC INFILTRATION; MYCOSIS FUNGOIDES; PRIORITY JOURNAL; SKIN DISEASE; SKIN TUMOR; T CELL LYMPHOMA; TISSUE DISTRIBUTION;

ANTIBODIES, NEOPLASM; ANTIGENS, CD7; DERMATITIS, CONTACT; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPHENOTYPING; LICHENOID ERUPTIONS; LYMPHOCYTES; LYMPHOMA, B-CELL; MYCOSIS FUNGOIDES; PARAFFIN EMBEDDING; PREDICTIVE VALUE OF TESTS; PSEUDOLYMPHOMA; SKIN NEOPLASMS;

EID: 0036161724     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000372-200202000-00002     Document Type: Article

References (62)

1. CD4+CD7- T cells: A separate subpopulation of memory T cells?
2. CD7-negative helper T cells accumulate in inflammatory skin lesions
3. CD7- T cells represent a subset of normal human blood lymphocytes
4. HLA-DR-positive leukocyte subpopulations in human skin include dendritic cells, macrophages, and CD7-negative T cells
5. Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor
6. Accumulation of CD4+CD7- T cells in inflammatory skin lesions: Evidence for preferential adhesion to vascular endothelial cells
7. CD4CD7 T cells compose the dominant T-cell clone in the peripheral blood of patients with Sézary syndrome
8. The usefulness of immunophenotypic and genotypic studies in the diagnosis and classification of hematopoietic and lymphoid neoplasms. An update
9. Detection of circulating T cells with CD4+CD7- immunophenotype in patients with benign and malignant lymphoproliferative dermatoses
10. Phenotypic characterization of skin-infiltrating T cells in cutaneous T-cell lymphoma: Comparison with benign cutaneous T-cell infiltrates
11. Phenotypic characterization of lymphocyte subsets in mycosis fungoides. Comparison with large plaque parapsoriasis and benign chronic dermatoses
12. Leu-8 and Leu-9 antigen phenotypes: Immunologic criteria for the distinction of mycosis fungoides from cutaneous inflammation
13. Reassessment of lymphocytic immunophenotyping in the diagnosis of patch and plaque stage lesions of mycosis fungoides
14. Lymphocytic antigen abnormalities in inflammatory dermatoses
15. Immunophenotyping and T-cell receptor gamma gene rearrangement analysis as an adjunct to the histopathologic diagnosis of mycosis fungoides
16. Atypical cutaneous lymphocytic infiltrate and a role for quantitative immunohistochemistry and gene rearrangement studies
17. Poikilodermatous mycosis fungoides and atrophic large-plaque parapsoriasis exhibit similar abnormalities of T-cell antigen expression
18. Discordant expression of antigens between intraepidermal and intradermal T cells in mycosis fungoides
19. Mycosis fungoides palmaris et plantaris
20. Analysis of clinical, histopathologic and immunopathologic parameters in erythrodermic variants of cutaneous T-cell lymphoma with implications for staging
21. Cutaneous T cell lymphoma with suppressor/cytotoxic (CD8) phenotype: Identification of rapidly progressive and chronic subtypes
22. Mycosis fungoides-type cutaneous T-cell lymphoma arising before 30 years of age. Immunophenotypic, immunogenotypic and clinicopathologic analysis of nine cases
23. Leu-8/CD7 antigen expression by CD3+ T cells: Comparative analysis of skin and blood in mycosis fungoides/Sézary syndrome relative to normal blood values
24. Integrins and homing receptors in cutaneous lymphomas
25. Detection of clonal T-cell receptor gamma gene rearrangements with the use of the polymerase chain reaction in cutaneous lesions of mycosis fungoides and Sézary syndrome
26. Pagetoid reticulosis (Woringer-Kolopp disease): An immunophenotypic, molecular, and clinicopathologic study
27. Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis?
28. Histologic criteria for the diagnosis of mycosis fungoides: Proposal for a grading system to standardize pathology reporting
29. Benign and malignant forms of erythroderma: Cutaneous immunophenotypic characteristics
30. Nuclear contour irregularity correlates with Leu-9-, Leu-8- cells in benign lymphoid infiltrates of skin. An ultrastructural morphometric and quantitative immunophenotypic analysis suggesting the normal T-cell counterpart to the malignant mycosis fungoides/Sézary cell
31. Characterization of the dermal infiltrates in Jessner's lymphocytic infiltrate of the skin, polymorphous light eruption and cutaneous lupus erythematosus: Differential diagnostic and pathogenetic aspects
32. Efficacy of histologic criteria for diagnosing early mycosis fungoides: An EORTC Cutaneous Lymphoma Study Group investigation
33. A new CD7 paraffin reactive antibody and T-γ PCR monoclonality are sensitive and specific for a diagnosis of mycosis fungoides (MF)
34. Optimizing immunohistochemistry: Antigen retrieval and signal amplification
35. The histologic spectrum of mycosis fungoides/Sézary syndrome (cutaneous T-cell lymphoma). A review of 222 biopsies, including newly described patterns and the earliest pathologic changes
36. Variants of mycosis fungoides and related cutaneous T-cell lymphomas
37. Cutaneous T-cell lymphoma. Evaluation of pretreatment skin biopsy specimens by a panel of pathologists
38. Accuracy, concordance, and reproducibility of histologic diagnosis in cutaneous T-cell lymphoma: An EORTC Cutaneous Lymphoma Project Group study
39. Nonerythrodermic, leukemic variant of cutaneous T-cell lymphoma with indolent clinical course: Th2-type tumor cells lacking T-cell receptor/CD3 expression and coinfiltrating tumoricidal CD8 T cells
40. Mycosis fungoides skin lesions contain CD8+ tumor-infiltrating lymphocytes expressing an activated, MHC-restricted cytotoxic T-lymphocyte phenotype
41. Isolation of tumor-specific cytotoxic CD4+ and CD4+CD8dim+ T-cell clones infiltrating a cutaneous T-cell lymphoma
42. Tumor-infiltrating lymphocytes isolated from a Ki-1-positive large cell lymphoma of the skin. Phenotypic characterization and analysis of cytokine secretion
43. CD4+ T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcome
44. Skewed expression of activation, differentiation and homing-related antigens in circulating cells from patients with cutaneous T cell lymphoma associated with CD7- T helper lymphocytes expansion
45. Immunophenotyping on simultaneously occurring plaques and tumors in mycosis fungoides and Sézary syndrome
46. Histologic and immunophenotypic features prior to transformation in patients with transformed cutaneous T-cell lymphoma: Is CD25 expression in skin biopsy samples predictive of large cell transformation in cutaneous T-cell lymphoma?
47. Immunohistologic markers for the diagnosis of cutaneous lymphomas
48. Atypical cutaneous lymphoproliferative disorder in patients with HIV infection
49. Decreased CD7 expression in cutaneous infiltrates of HIV-1+ patients. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR)
50. Detection of clonal T-cell receptor gamma gene rearrangements in early mycosis fungoides/Sézary syndrome by polymerase chain reaction and de-naturing gradient gel electrophoresis (PCR/DGGE)
51. Persistent pigmented purpuric dermatitis and mycosis fungoides: Simulant, precursor, or both? A study by light microscopy and molecular methods
52. Genotypic analysis in cutaneous lymphoproliferative disease - A reliable test?
53. Clonal T-cell populations in pityriasis lichenoides et varioliformis acura (Mucha-Habermann disease)
54. The natural history of parapsoriasis en plaques (chronic superficial dermatitis) and prereticulotic poikiloderma
55. Variable course of patients with plaque psoriasis: Lack of transformation into tumorous mycosis fungoides
56. Malignancy in scars, chronic ulcers and sinuses
57. Molecular mechanisms for inflammation-promoted pathogenesis of cancer - The Sixteenth International Symposium of the Sapporo Cancer Seminar
58. Medical history and the risk of non-Hodgkin's lymphomas
59. Malignant tumors of the stomach. Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori
60. Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion
61. Lymphocytes infiltrating primary cutaneous neoplasms selectively express the cutaneous lymphocyte-associated antigen (CLA)
62. A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites