Accumulation of CD4+CD7- T cells in inflammatory skin lesions: Evidence for preferential adhesion to vascular endothelial cells

Clinical and Experimental Immunology

Volumn 121, Issue 1, 2000, Pages 94-99

  Liu, L ^a,c   Abken, H ^b   Pfohler C ^a   Rappl, G ^a   Tilgen, W ^a   Reinhold, Uwe ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

CD7 ; Endothelial cells; Skin inflammation; T cells; Vascular adhesion

Indexed keywords

CD4 ANTIGEN; CD7 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; LIGAND; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL SUBPOPULATION; HELPER CELL; INFLAMMATORY CELL; LIGAND BINDING; LYMPHOMA CELL; MEMORY CELL; PRIORITY JOURNAL; SKIN DEFECT; SKIN INFLAMMATION;

ANTIGENS, CD7; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; ECZEMA; ENDOTHELIUM, VASCULAR; EPIDERMIS; HUMANS; IMMUNOLOGIC MEMORY; KERATINOCYTES; PSORIASIS; SKIN; SKIN DISEASES; T-LYMPHOCYTE SUBSETS;

EID: 0033931442     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01260.x     Document Type: Article

References (37)

1. Shimizu Y, Newman W, Tanaka Y et al. Lymphocyte interactions with endothelial cells. Immunol Today 1992; 13:106-12.
2. Springer TA. Adhesion receptors of the immune system. Nature 1990; 346:425-34.
3. Mobley JL, Reynolds PJ, Shimizu Y. Regulatory mechanisms underlying T cell integrin receptor function. Sem Immunol 1993; 5:227-36.
4. Dustin ML, Springer TA. Lymphocyte function associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for T lymphocyte adhesion to cultured endothelial cells. J Cell Biol 1988; 107:321-31.
5. Picker LJ, Michie LS, Rott LS et al. A unique phenotype of skin-associated lymphocytes in humans. Am J Pathol 1990; 136:1053-67.
6. Picker LJ, Kishimoto TK, Smith CW et al. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 1991; 349:796-9.
7. - T cells represent a subset of normal human blood lymphocytes. J Immunol 1993; 150:2081-9.
8. - T cells in human blood lymphocytes with ageing. Clin Exp Immunol 1994; 98:163-8.
9. Haynes BF, Mann DL, Hemler ME et al. Characterization of a monoclonal antibody which defines an immunoregulatory T cell subset for immunoglobulin synthesis in man. Proc Natl Acad Sci USA 1980; 77:2914-8.
10. Junf LKL, Fu SM, Hara T et al. Defective expression of T-cell associated glycoprotein in severe combined immunodeficiency. J Clin Invest 1986; 77:940-6.
11. Haynes BF, Metzgar S, Minna JD et al. Phenotypic characterization of cutaneous T-cell lymphoma. Use of monoclonal antibodies to compare with other malignant T cells. N Engl J Med 1981; 22:602-7.
12. - T helper cells from normal donors and HIV-infected patients. J Immunol 1995; 154:1408-17.
13. Foster CA, Yokozeki H, Rappersberger K et al. Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor. J Exp Med 1990; 171:997-1013.
14. Davis AL, McKenzie JL, Hart DNJ. HLA-DR-positive leukocyte subpopulations in human skin include dendritic cells, macrophages, and CD7-negative T cells. Immunology 1988; 65:573-81.
15. Moll M, Reinhold U, Kukel S et al. CD7-negative helper T cells accumulate in inflammatory skin lesions. J Invest Dermatol 1994; 102:328-32.
16. Feller AC, Parwaresch MR, Wacker HH et al. Combined immunohistochemical staining for surface IgD and T-lymphocyte subsets with monoclonal antibodies in human tonsils. Histochem J 1983; 15:557-62.
17. 2+-dependent association with sites of cell-cell contact. J Cell Biol 1989; 109:557-69.
18. Reinhold U, Liu L, Sesterhenn J et al. CD7-negative T cells represent a separate differentiation pathway in a subset of postthymic helper T cells. Immunology 1996; 89:391-6.
19. - T helper cells from normal donors and HIV-infected patients. J Immunol 1995; 154:1408-17.
20. Vonderheid EC, Bigler RD, Greenberg AS et al. Extracorporal photopheresis and recombinant interferon-alpha 2b in Sezary syndrome. Use of dual marker labeling to monitor therapeutic response. Am J Clin Oncol 1994; 17:255-63.
21. Smith KJ, Skelton HG, Chu W et al. Decreased CD7 expression in cutaneous infiltrates of HIV+ patients. Am J Dermatopathol 1995; 17:564-9.
22. Haskard D, Cavender D, Fleck RM et al. Human dermal microvascular endothelial cells behave like umbilical vein endothelial cells in T-cell adhesion studies. J Invest Dermatol 1987; 88:340-4.
23. Shimizu Y, Newman W, Gopa TV et al. Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions. J Cell Biol 1991; 113:1203-12.
24. Damle NK, Doyle LV. Ability of human T lymphocytes to adhere to vascular endothelial cells and to augment endothelial permeability to macromolecules is linked to their state of post-thymic maturation. J Immunol 1990; 144:1233-40.
25. Sanders ME, Makoba MW, Sharrow SO et al. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol 1988; 140:1401-7.
26. Bos JD, Hagenaars C, Das PK et al. Predominance of 'memory' T cells (CD4+CDw29+) over 'naive' T cells (CD4+CD45R+) in both normal and diseased human skin. Arch Dermatol 1989; 281:24-30.
27. Parrot DM, Wilkinson PC. Lymphocyte locomotion and migration. Prog Allergy 1981; 28:193-248.
28. Hanto DW, Hopt UT, Hoffman R et al. Lymphocyte recruitment, regional blood flow, and vascular permeability at sites of allogeneic cellular interactions. J Immunol 1982; 129:2437-43.
29. Groves RW, Allen MH, Barker JNWN et al. Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. Br J Dermatol 1991; 124:117-23.
30. Reinhold U, Abken H. Cutaneous T cell lymphoma: molecular genetics, immunology and pathogenesis. Eur J Cancer 1995; 31A:793-9.
31. Hansen ER, Vejlsgaard GL, Lisby S et al. Epidermal interleukin 1 alpha functional activity and interleukin 8 immunoreactivity are increased in patients with cutaneous T-cell lymphoma. J Invest Dermatol 1991; 97:818-23.
32. Wismer JM, McKenzie RC, Sauder DN. Interleukin-8 immunoreactivity in epidermis of cutaneous T-cell lymphoma patients. Lymphokine Res 1994; 13:21-27.
33. Babi LF, Moser R, Soler MTP et al. Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 1995; 154:1543-50.
34. - T cells. Clin Exp Immunol 1996; 106:555-9.
35. Gleich GJ, Adophson CR. The eosinophilic leukocyte: structure and function. Adv Immunol 1986; 39:177-253.
36. Yamaguchi Y, Suda T, Ohta S et al. Analysis of the survival of mature human eosinophils: interleukin 5 prevents apoptosis in mature human eosinophils. Blood 1991; 78:2543-7.
37. - T cells expressing interleukin-5 mRNA. Br J Dermatol 1997; 136:918-23.