Molecular determinants of opioid analgesia: Modulation of presynaptic calcium channels

Drug Development Research

Volumn 54, Issue 3, 2001, Pages 118-128

  Beedle, Aaron M ^a   Zamponi, Gerald W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

GRK; GTP binding proteins; Opioid receptors; RGS; arrestin

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN; OPIATE AGONIST; OPIATE RECEPTOR; POTASSIUM CHANNEL;

ANALGESIA; HUMAN; PAIN; PATHOPHYSIOLOGY; PRESYNAPTIC NERVE; REVIEW;

EID: 0036159679     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10026     Document Type: Review

References (4)

1. Arnot MI, Stotz SC, Jarvis SE, Zamponi GW.2000. Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms. J Physiol 527:203-212.
2. Dean BP. 1989. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340: 153-156.
3. Bech-Hansen NT, Naylor MJ, Maybaum TA, Pearce WG, Koop B, Fishman GA, Mets M, Musarella MA, Boycott KM. 1998. Loss-of-function mutations in a calcium-channel alphal-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Nat Genet 19:264-267.
4. Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. 1999. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286:2493-2498.