Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat

Journal of Lipid Research

Volumn 43, Issue 1, 2002, Pages 59-68

  Rosenberger, Thad A ^a   Oki, Jun ^a   Purdon, A David ^a   Rapoport, Stanley I ^a   Murphy, Eric J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Autoradiography; Brain; Half life; Hexadecanol; Microsome; Myelin; Peroxisome; Plasmalogen; Synapses; Synaptosome

Indexed keywords

2 ACYL 1 ALKYLGLYCEROPHOSPHORYLETHANOLAMINE; CHOLINE; ETHANOLAMINE; ETHER PHOSPHOLIPID; GLYCEROPHOSPHATE; HEXADECANOL; MYELIN; PLASMANYLCHOLINE; PLASMENYLCHOLINE; PLASMENYLETHANOLAMINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BIOACCUMULATION; BRAIN MICROSOME; BRAIN SYNAPTOSOME; CALCULATION; COMPARTMENT MODEL; CONTINUOUS INFUSION; CONTROLLED STUDY; FRACTIONATION; GRAY MATTER; HALF LIFE TIME; ISOTOPE LABELING; MALE; NONHUMAN; PHOSPHOLIPID METABOLISM; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL TRANSPORT; BRAIN; CHOLINE; ETHANOLAMINE; FATTY ALCOHOLS; HALF-LIFE; MALE; MICROSOMES; PHOSPHOLIPID ETHERS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOSOMES;

EID: 0036158985     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Phospholipids and the nervous system
2. Positions of double bonds in the monounsaturated alk-1-enyl groups form the plasmalogens of human heart and brain
3. Structure of neutral glycerides and phosphoglycerides of human kidney
4. Antihypertensive activity of an alkyl ether analog of phosphatidylcholine
5. Composition of myelin from peripheral and central nervous system of the squirrel monkey
6. The maturation of rat brain myelin
7. Acyl-GPC and alkenyl/alkyl-GPC:acyl-CoA acyltransferases
8. Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells
9. Studies on the hydrolysis of 1-alk-1′-enyl-sn-glycero-3-phosphoethanolamine by microsomes from myelinating rat brain
10. Alkenylhydrolase: A microsomal enzyme activity in rat brain
11. Phospholipase D hydrolysis of plasmalogen and diacyl ethanolamine phosphoglycerides by protein kinase C dependent and independent mechanisms
12. 2 and its role in brain tissue
13. 2 from bovine brain cytosol
14. Studies on the hydrolysis of 1-alkyl-sn-glycero-3-phosphoethanolamine in subcellular fractions of rat brain
15. Platelet-activating factor: A case for its role in CNS function and brain injury
16. Platelet-activating factor receptor: Gene expression and signal transduction
17. Plasmenylethanolamine facilitates rapid membrane fusion: A stopped-flow kinetic investigation correlating the propensity of a major plasma membrane constituent to adopt an HII phase with its ability to promote membrane fusion
18. Impaired membrane traffic in defective ether lipid biosynthesis
19. 2 and signal transduction
20. Plasmalogens as endogenous antioxidants: Somatic cell mutants reveal the importance of the vinyl ether
21. Ether lipids in biomembranes
22. Biosynthesis and possible biological functions of plasmalogens
23. Enzymic synthesis of 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamines by the CDP-ethanolamine: 1-radyl-2-acyl-sn-glycerol ethanolaminephosphotransferase from microsomal fraction of rat brain
24. Metabolism of palmitic acid in the subcellular fractions of mouse brain
25. Enzymic synthesis of ether types of choline and ethanolamine phosphoglycerides by microsomal fractions from rat brain and liver
26. Kinetics of the biosynthesis of phospholipids in neurons and glial cells isolated from rat brain cortex
27. Metabolism of glycerophospholipids of myelin and microsomes in rat brain. Reutilization of precursors
28. On the calculation of "turnover time" and "turnover rate" from experiments involving the use of labeling agents
29. Turnover rates of the molecular species of ethanolamine plasmalogen of rat brain
30. Recent developments in the turnover of proteins and lipids in myelin and other plasma membranes in the central nervous system
31. In vivo imaging of fatty acid incorporation into brain to examine signal transduction and neuroplasticity involving phospholipids
32. Glycerolipid biosynthesis in peroxisomes (microbodies)
33. 3H]arachidonate in the anesthetized rat
34. Membrane phospholipid alterations in Alzheimer's disease: Deficiency of ethanolamine plasmalogens
35. The morphology of fractions of rat forebrain synaptosomes separated on continuous sucrose density gradients
36. Metabolism of the ethanolamine phosphoglycerides of mouse brain myelin and microsomes
37. The acyl and alk-1-enyl groups of the major phosphoglycerides from ox brain myelin and mouse brain microsomal, mitochondrial and myelin fractions
38. Effects of ethanol on the activity of adenosine triphosphatase and acetylcholinesterase in synaptosomes isolated from guinea-pig brain
39. The effect of phospholipase C on the activity of adenosine triphosphatase and acetylcholinesterase in synaptic membranes isolated from the cerebral cortex of squirrel monkey
40. 3H] palmitic acid incorporation into brain lipids
41. A simple method for the isolation and purification of total lipides from animal tissue
42. Fatty acid binding protein: Stimulation of microsomal phosphatidic acid formation
43. The alkaline hydrolysis of the ethanolamine plasmalogen of brain tissue
44. Quantitative analysis of phospholipids by thin-layer chromatography and phosphorus analysis of spots
45. Specific distribution of short-chain fatty acids in molecular distillates of bovine milk fat
46. Specific activity of brain palmitoyl-CoA pool provides rates of incorporation of palmitate in brain phospholipids in awake rats
47. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: Review and critical analysis
48. Delivery and turnover of plasma-derived essential PUFAs in mammalian brain
49. The study of metabolic turnover rates by means of isotopic tracers. I. Fundamental relations
50. Fatty alcohol metabolism in cultured human fibroblasts. Evidence for a fatty alcohol cycle
51. Partition coefficients and their uses
52. Studies on the cellular mechanism of free fatty acid uptake using an analog, hexadecanol
53. Lipid turnover
54. Incorporation of plasma palmitate into the brain of the rat during development
55. 32P into the phosphatides of myelin sheaths and of intracellular membranes
56. Ether-linked lipids and fatty alcohol precursors in neoplasms
57. Alkyl-dihydroxyacetonephosphate synthase: Presence and role of flavin adenine dinucleotide
58. 3H]dihydroxyacetone-P by purified alkyldihydroxyacetone-P synthase in the absence of acylhydrolase activity