Platelet-activating factor: A case for its role in CNS function and brain injury

Journal of Lipid Mediators and Cell Signalling

Volumn 14, Issue 1-3, 1996, Pages 109-114

  Feuerstein, Giora Z ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 [2 [[5 (N OCTADECYLCARBAMOYLOXYMETHYL)TETRAHYDROFURFURYLOXY]HYDROXYPHOSPHINYLOXY]ETHYL]QUINOLINIUM; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; 6 (2 CHLOROPHENYL) 9 [(3,4 DIMETHOXYPHENYL)THIOMETHYLTHIOCARBONYL] 4,7,8,10 TETRAHYDRO 1 METHYLPYRIDO[4',3':4,5]THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN; APAFANT; BRADYKININ; CALCIUM; DILTIAZEM; ENDOTHELIN; GINKGOLIDE B; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KADSURENONE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID; NIFEDIPINE; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; UNINDEXED DRUG;

ANIMAL MODEL; BIOSYNTHESIS; BRAIN FUNCTION; BRAIN INJURY; BRAIN ISCHEMIA; CONFERENCE PAPER; DRUG INHIBITION; HUMAN; MEDIATOR; NONHUMAN; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 0030248904     PISSN: 09297855     EISSN: None     Source Type: Journal    
DOI: 10.1016/0929-7855(96)00516-0     Document Type: Conference Paper

References (10)

1. Yue, T-L., Lysko, P. and Feuerstein, G. (1990) Production of platelet-activating factor from rat cerebellar granule cells in culture. J. Neurochem. 54, 1809-1811.
2. Sogos, V., Bussolino, F., Pilia, E., Torelli, S. and Gremo, F. (1990) Acetylcholine-induced production of platelet-activating factor by human fetal brain cells in culture. J. Neurosci. Res. 27, 706.
3. Lindsberg, P.J., Frerich, K., Hallenbeck, J.M. and Feuerstein, G. (1990) Evidence for platelet-activating factor as a novel mediator in experimental stoke in rabbits. Stroke 21, 1452-1457.
4. Domingo, M.T., Spinnewyn, B., Chabrter, P.E. and Braquet, P. (1988) Presence of specific binding sites for platelet-activating factor (PAF) in brain. Biochem. Biophys. Res. Commun. 151, 730.
5. Yue, T.-L., Gleason, M.M. and Feuerstein, G. (1991a) Characterization of platelet activating factor (PAF)-induced elevation of cytosolic free calcium level in neurohybrid NCB-20 cells. Neuroscience 141, 177-185.
6. Yue, T.-L., Gleason, M.M., Gu, J.L., Lysko, P.G., Hallenbeck, J.M. and Feurestein, G. (1991b) Platelet-activating factor (PAF) receptor mediated calcium mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells: studies with BN50739, a new PAF antagonist. J. Pharmacol. Expl. Ther. 257, 374-381.
7. Yue, T.-L., Stadel, J.M., Sarau, H.M. et al. (1992a) Platelet-activating factor (PAF) stimulates phosphoinositide turnover in neurohybrid NCB-20 cells. Involvement of a pertussis toxin-sensitive G protein and inhibition by protein kinase C. Mol. Pharmacol. 41: 281-289.
8. + mobilization and phosphoinositide turnover in neurohybrid NG 108-15 cells. Neurochem. Res. 175, 997-1004.
9. Jiang, Z.G., Yue, T.-L. and Feuerstein, G. (1993) Platelet-activating factor inhibits excitatory transmission in rat neostriatu. Neurosci. Lett. 155, 132-135.
10. 10. Yue, T.-L. and Feurstein, G. (1994) Platelet-activating factor: a putative neuromodulator and mediator in the pathophysiology of brain injury. Crit. Rev. Neurobiol. 8, 11-24.