Just say NO to muscle degeneration?

Trends in Molecular Medicine

Volumn 8, Issue 2, 2002, Pages 51-53

  Froehner, Stanley C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYSTROPHIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

BIOSYNTHESIS; DISEASE COURSE; DUCHENNE MUSCULAR DYSTROPHY; GENE MUTATION; GENE REPLACEMENT THERAPY; HUMAN; INFLAMMATORY CELL; MUSCLE ATROPHY; MUSCLE CONTRACTION; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; REVIEW; SARCOLEMMA; SIGNAL TRANSDUCTION;

ANIMALS; DYSTROPHIN; GENE THERAPY; HUMANS; MICE; MODELS, BIOLOGICAL; MUSCLES; MUSCULAR DYSTROPHY, DUCHENNE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

EID: 0036156341     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02275-X     Document Type: Review

References (20)

1. A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice
2. Dystrophin and the membrane skeleton
3. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy
4. Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals
5. Two forms of mouse syntrophin, a 58-kd dystrophin -associated protein, differ in primary structure and tissue distribution
6. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
7. Absence of α-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin
8. α-syntrophin gene disruption results in the absence of neuronal·type nitric oxide synthase at the sarcolemma but does not induce muscle degeneration
9. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin·associated proteins
10. Stress-activated protein kinase-3 interacts with the PDZ domain of α1-syntrophin, a mechanism for specific substrate recognition
11. Interactions between β2-syntrophin and a family of microtubule-associated serine/threonine kinases
12. Interaction of γ1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions
13. In vivo requirement of the α-syntrophin PDZ domain in the sarcolemmal localization of nNOS and aquaporin-4
14. mdx muscle pathology is independent ofnNOS perturbation
15. Impaired metabolic modulation of α·adrenergic vasoconstriction in dystrophin-deficient skeletal muscle
16. Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy
17. Physiology of nitric oxide in skeletal muscle
18. Molecular pathophysiology and targeted therapeutics for muscular dystrophy
19. Regulation of neuronal nitric·oxide synthase by calmodulin kinases
20. PIN: An associated protein inhibitor of neuronal nitric oxide synthase