All-trans retinoic acid induces differentiation and apoptosis of murine melanocyte precursors with induction of the microphthalmia-associated transcription factor

Journal of Investigative Dermatology

Volumn 118, Issue 1, 2002, Pages 35-42

  Watabe, Hidenori ^a   Soma, Yoshinao ^a   Ito, Masaru ^a   Kawa, Yoko ^a   Mizoguchi, Masako ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

bcl 2; Caspase 3; Melanogenesis; Protein kinase Ca retinoic acid

Indexed keywords

DOPA; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; PROTEIN BCL 2; PROTEIN KINASE C ALPHA; RETINOIC ACID; STEM CELL FACTOR; TRANSCRIPTION FACTOR; TYROSINASE RELATED PROTEIN 1; TYROSINASE RELATED PROTEIN 2;

ANALYTIC METHOD; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL MATURATION; CELL SHAPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME MECHANISM; ENZYME REGULATION; GENE EXPRESSION REGULATION; MELANOCYTE; MELANOGENESIS; MELANOSOME; MICROPHTHALMIA; MOUSE; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RODENT; STEM CELL;

EID: 0036156268     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01614.x     Document Type: Article

References (47)

1. Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids
2. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation
3. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients
4. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia
5. Differential expression and ligand regulation of the retinoic acid receptor α and β genes
6. Different susceptibilities of melanoma cells to retinoic acid-induced changes in melanotic expression
7. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis
8. Identification of a receptor for the morphogen retinoic acid
9. Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial
10. Increased expression of protein kinase Cα plays a key role in retinoic acid-induced melanoma differentiation
11. Retinoic acid specifically increases nuclear PKCα and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells
12. Topical retinoic acid augments ultraviolet light-induced melanogenesis
13. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
14. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXRα, RXRβ, and RXRγ
15. A helix-loop-helix transcription factor-like gene is located at the mi locus
16. In vitro clonal analysis of mouse neural crest development
17. Removal of stem cell factor or addition of monoclonal anti-c-KIT antibody induces apoptosis in murine melanocyte precursors
18. Tyrosinase from two different loci are expressed by normal and by transformed melanocytes
19. Stem cell factor and/or endothelin-3 dependent immortal melanoblast and melanocyte populations derived from mouse neural crest cells
20. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
21. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
22. Stimulation of melanogenesis in a human melanoma cell line by retinoids
23. Characterization of the inhibitory effects of retinoids on the in vitro growth of two malignant murine melanomas
24. Retinoic acid increases cyclic AMP-dependent protein kinase activity in murine melanoma cells
25. Nuclear receptor that identifies a novel retinoic acid response pathway
26. Characterization of the effects of different retinoids on the growth and differentiation of a human melanoma cell line and selected subclones
27. Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest
28. Caspase: Killer proteases
29. Induction of protein kinase C in mouse melanoma cells by retinoic acid
30. In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: Two distinct waves of c-kit-dependency during melanocyte development
31. Development of melanocytes progenitors in murine steel mutant neural crest explants cultured with stem cell factor, endothelin-3, or TPA
32. Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines
33. A human retinoic acid receptor which belongs to the family of nuclear receptors
34. Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage
35. Bcl-2 and the regulation of programmed cell death
36. Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development
37. Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A
38. MITF: A stream flowing for pigment cells
39. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p 12.3
40. Differential regulation of tyrosinase activity in skin of white and black individuals in vivo by topical retinoic acid
41. A second tyrosinase related protein, TRP-2 is a melanogenic enzyme termed DOPA chrome tautomerase
42. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
43. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
44. Topical all-trans retinoic acid augments ultraviolet radiation-induced increases in activated melanocyte numbers in mice
45. Cell death: The significance of apoptosis
46. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene
47. Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes