Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice

Journal of Investigative Medicine

Volumn 50, Issue 1, 2002, Pages 54-60

  Christofidou Solomidou, Melpo ^a   Scherpereel, Arnaud ^a   Solomides, Charalambos C ^a   Christie, Jason O ^a   Stossel, Thomas P ^a   Goelz, Susan ^a   DiNubile, Mark J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Actin; Acute lung injury; Gelsolin; Hyperoxia; Inflammation

Indexed keywords

ACTIN; BOVINE SERUM ALBUMIN; GELSOLIN; LYSOPHOSPHATIDIC ACID;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EXUDATE; HYPEROXIA; IMMUNOMODULATION; INFLAMMATION; LUNG INJURY; LUNG LAVAGE; LUNG VENTILATION; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; RESPIRATORY DISTRESS;

ANIMALIA; BOVINAE;

EID: 0036155795     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2002.33518     Document Type: Article

References (44)

1. Clinical risks for development of the acute respiratory distress syndrome
2. The acute respiratory distress syndrome
3. Biological markers of acute lung injury: Prognostic and pathogenic significance
4. A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure
5. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome
6. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
7. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
8. Acute lung injury in the medical ICU: Comorbid conditions, age, etiology, and hospital outcome
9. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993
10. Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice
11. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
12. Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia
13. Morphologic changes in pulmonary oxygen toxicity
14. Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cell
15. Angiopathic consequences of saturating the plasma scavenger system for actin
16. The extracellular actin-scavenger system and actin toxicity
17. Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation
18. Role of group-specific component (vitamin D-binding protein) in clearance of actin from the circulation in the rabbit
19. Capacity of human serum to depolymerize actin filaments
20. Coordinated inhibition of actin-induced platelet aggregation by plasma gelsolin and vitamin D-binding protein
21. Gelsolin activates DNase I in vitro and in cystic fibrosis sputum
22. Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid
23. Gelsolin binding and cellular presentation of lysophosphatidic acid
24. Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction
25. Phospholipid synthesis in isolated alveolar type II cells exposed in vitro to paraquat and hyperoxia
26. Circulating actin-gelsolin complexes following oleic acid-induced lung injury
27. Reduction of hyperoxic lung injury in mice by infusions of recombinant plasma gelsolin
28. Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury
29. Relationship of admission gelsolin levels to clinical outcomes in patients after major trauma
30. Gelsolin depletion correlates with oxidant-induced acute lung injury in mice
31. Immuno-targeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs
32. Lack of detectable enhanced pulmonary histopathology in cotton rats immunized with purified F glycoprotein of respiratory syncytial virus (RSV) when challenged at 3-6 months after immunization
33. Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome
34. The modulation of oxygen toxicity by intermittent exposure
35. Correlation between lung injury score and serum albumin levels in patients at risk for developing acute lung injury
36. Human albumin administration in critically ill patients: Systematic review of randomized controlled trials
37. Intercellular adhesion molecule-1 contributes to pulmonary oxygen toxicity in mice: Role of leukocytes revised
38. Polymorphonuclear leukocyte participation in acute oleic-acid-induced lung injury
39. The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats
40. Lisofylline prevents leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally
41. Reactive oxygen species in acute lung injury
42. Alveolar neutrophils in endotoxin-induced and bacteria-induced acute lung injury in rats
43. The importance of polymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production and lung injury: Ex vivo observation in rat lungs
44. Lipopolysaccharide-induced lung injury in mice. I. Concomitant evaluation of inflammatory cells and hemorrhagic lung damage