Life and death in the gut: More killing, less Crohn's

Gut

Volumn 50, Issue 2, 2002, Pages 148-149

  Sturm, A ^a   Fiocchi, C ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLIXIMAB; TUMOR NECROSIS FACTOR ANTIBODY;

APOPTOSIS; CELL PROLIFERATION; CROHN DISEASE; CYTOKINE PRODUCTION; HUMAN; LEUKEMIA CELL LINE; OUTCOMES RESEARCH; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL DIVISION; CROHN DISEASE; GASTROINTESTINAL AGENTS; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 0036151032     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.50.2.148     Document Type: Short Survey

References (16)

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2. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
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4. Anti-TNFα therapy of rheumatoid arthritis: What have we learned?
5. Tumor necrosis factor: Biology and therapeutic inhibitors
6. Tumor necrosis factor α antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
7. Apoptosis in the pathogenesis and treatment of disease
8. T cell death and memory
9. Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis
10. Resistance of Crohn's disease T-cells to multiple apoptotic stimuli is associated with a Bcl-2/Bax mucosal imbalance
11. Decreased Bax expression by mucosal T-cells favours resistance to apoptosis in Crohn's disease (CD)
12. Anti-interleukin-12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice
13. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
14. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7)
15. Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease
16. Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: A pilot study