Rapid screening assay of congenital adrenal hyperplasia by measuring 17α-hydroxyprogesterone with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry from dried blood spots

Journal of Clinical Laboratory Analysis

Volumn 16, Issue 1, 2002, Pages 20-25

  Lai, Chien Chen ^a   Tsai, Chang Hai ^a   Tsai, Fuu Jen ^a   Wu, Jer Yuarn ^a   Lin, Wei De ^a   Lee, Cheng Chun ^a  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Corticosteroid; Electrospray; Enzymatic defect; HPLC MS MS; Metabolic disorders; MS MS; Newborn screening

Indexed keywords

HYDROXYPROGESTERONE; STEROID 21 MONOOXYGENASE;

ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; CHEMICAL STRUCTURE; CONGENITAL ADRENAL HYPERPLASIA; DIAGNOSTIC ACCURACY; ENZYME DEFECT; GAS CHROMATOGRAPHY; HUMAN; INFANT; MASS SPECTROMETRY; MICROTITER PLATE ASSAY; NEWBORN; NEWBORN SCREENING; PATIENT MONITORING; QUANTITATIVE ASSAY; SCREENING TEST; STEROID 21 MONOOXYGENASE DEFICIENCY;

17-ALPHA-HYDROXYPROGESTERONE; ADRENAL HYPERPLASIA, CONGENITAL; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INFANT, NEWBORN; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0036149535     PISSN: 08878013     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcla.2039     Document Type: Article

References (25)

1. Worldwide experience in newborn screening for classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency
2. Cortisol in dried blood screening specimens from newborns with raised 17-hydroxyprogesterone and congenital adrenal hyperplasia
3. Comparison of three methods for 17 alpha-hydroxyprogesterone
4. Plasma 17-hydroxyprogesterone determination with two commercial immunoassays
5. Identification of the steroids in neonatal plasma that interfere with 17 alpha-hydroxy-progesterone radioimmunoassays
6. Problems in diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
7. The quality assessment of steroid hormone assays
8. 17 Alpha-hydroxy-progesterone, 4-androstenedione, and testosterone profiled by routine stable isotope dilution/gas chromatography-mass spectrometry in plasma of children
9. Hormonal diagnosis of 21-hydroxylase deficiency in plasma and urine of neonates using bench top gas chromatography-mass spectrometry
10. Tandem mass spectrometry: A new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism
11. Rapid diagnosis of homocystinura and other hypermethioninemias from newborn's blood spots by tandem mass spectrometry
12. Application of electrospray tandem mass spectrometry to neonatal screening
13. On-line derivatization of peptides for improved sequence analysis by micro-column liquid chromatography coupled with electrospray ionization-tandem mass spectrometry
14. LC/MS applications in drug development
15. High-throughput quantitative bioanalysis by LC/MS/MS
16. Rapid determination of corticosteroids in urine by combined solid phase microextraction/liquid chromatography/mass spectrometry
17. A high-performance liquid chromatography-electrospray-tandem mass spectrometry analysis of cortisol and metabolites in placental perfusate
18. Identification of main corticosteroids as illegal feed additives in milk replacers by liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry
19. A confirmatory HPLC-MS/MS method for ten synthetic corticosteroids in bovine urines
20. Collision-induced dissociation of corticosteroids in electrospray tandem mass spectrometry and development of a screening method by high performance liquid chromatography/tandem mass spectrometry
21. Electrospray collision-induced dissociation of testosterone and testosterone hydroxy analogs
22. Preliminary result of neonatal screening of congenital adrenal hyperplasia in Taiwan