Ion trap MSn for identification of gliotoxin as the cytotoxic factor of a marine strain of Aspergillus fumigatus Fresenius

Journal of Microbiological Methods

Volumn 48, Issue 2-3, 2002, Pages 171-179

  Grovel, O ^a   Pouchus, Y F ^a   Robiou Du Pont, T ^a   Montagu, M ^a   Amzil, Z ^b   Verbist, J F ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b IFREMER   (France)

Author keywords

Aspergillus fumigatus; Cytotoxicity; Gliotoxin; Ion trap electrospray mass spectrometry; Shellfish

Indexed keywords

CYTOTOXIC FACTOR; DISULFIDE; GLIOTOXIN; ION; SODIUM; SULFUR;

ARTICLE; ASPERGILLUS FUMIGATUS; ATOM; BIOASSAY; CONTROLLED STUDY; CYTOTOXICITY TEST; EXTRACTION; FRANCE; FUNGUS GROWTH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PURIFICATION; SHELLFISH;

ANIMALS; ASPERGILLUS FUMIGATUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLIOTOXIN; HUMANS; KB CELLS; MASS SPECTROMETRY; SHELLFISH; WATER MICROBIOLOGY;

ASPERGILLUS; ASPERGILLUS FUMIGATUS;

EID: 0036149416     PISSN: 01677012     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7012(01)00321-9     Document Type: Article

References (27)

1. Rapid analysis of antibiotic-containing mixtures from fermentation broths by using liquid chromatography-electrospray ionization-mass spectrometry and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
2. Short-time cytotoxicity of mussel extracts: A new bio-assay for okadaic acid detection
3. Isolation of a mycotoxin (gliotoxin) from a bovine udder infected with Aspergillus fumigatus
4. Determination of optimum growth conditions for gliotoxin production by Aspergillus fumigatus and development of a novel method for gliotoxin detection
5. Biosynthetic studies on gliotoxin using stable isotopes and mass spectral methods
6. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus: I. Taxonomy, fermentation, isolation and biological properties
7. Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase
8. Isolation, structure determination and biological activities of novel mammalian cell cycle inhibitors, spirotryprostatins A and B, tryprostatins A and B and related new diketopiperazine derivatives produced by a fungus, Aspergillus fumigatus
9. Nouvelles toxines d'Aspergillus fumigatus Fresenius
10. The effect of gliotoxin upon macrophage function
11. Structural determination and quantitative analysis of bacterial phospholipids using liquid chromatography/electrospray ionization/mass spectrometry
12. High sensitivity identification of proteins by electrospray ionization tandem mass spectrometry: Initial comparison between an ion trap mass spectrometer and a triple quadrupole mass spectrometer
13. Electrospray mass spectrometry - The ultimate HPLC detector?
14. Mechanism of gliotoxin action and factors mediating gliotoxin sensitivity
15. Quantitative determination of ochratoxin A by liquid chromatography/electrospray tandem mass spectrometry
16. Diffusible component from the spore surface of the fungus Aspergillus fumigatus which inhibits the macrophage oxidative burst is distinct from gliotoxin and other hyphal toxins
17. Gliotoxin induces apoptosis in mouse L929 fibroblast cells
18. Combined use of analytical high-performance liquid chromatography and cell morphology transformation assay to detect new protein phosphatase inhibitors of okadaic acid type
19. Use of thin layer chromatography for detection and high performance liquid chromatography for quantitating gliotoxin from rice cultures of Aspergillus fumigatus Fresenius
20. Natural occurrence of gliotoxin in turkeys infected with Aspergillus fumigatus, Fresenius
21. Toxigenic saprophytic fungi in marine shellfish farming areas
22. Determination of the Fusarium mycotoxins, fusaproliferin and beauvericin by high-performance liquid chromatography-electrospray ionization mass spectrometry
23. High-performance liquid chromatographic-electrospray ionization mass spectrometric analyses for the integration of natural products with modern high-throughput screening
24. Fumiquinazolines A-G, novel metabolites of a fungus separated from a Pseudolabrus marine fish
25. Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin
26. Determination of zearalenone in grains by high-performance liquid chromatography-tandem mass spectrometry after solid-phase extraction with RP-18 columns or immunoaffinity columns