메뉴 건너뛰기




Volumn 52, Issue 1, 2002, Pages 27-33

Synthesis, enantioseparation and pharmacological activity of 4-aryl-7,7-dimethyl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thiones

Author keywords

1,2,3,4,5,6,7,8 Octahydroquinazoline 2 thiones, calcium antagonist activity, enantioseparation, synthesis; Calcium antagonists

Indexed keywords

7,7 DIMETHYL 5 OXO 1,2,3,4,5,6,7,8 OCTAHYDROQUINAZOLINE 2 THIONE DERIVATIVE; ALDEHYDE; AMYLOSE; AROMATIC COMPOUND; CALCIUM ANTAGONIST; THIOUREA; UNCLASSIFIED DRUG;

EID: 0036147996     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299852     Document Type: Article
Times cited : (34)

References (27)
  • 1
  • 2
    • 0024427853 scopus 로고
    • Dihydropyrimidines: Novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity
    • (1989) J. Med. Chem. , vol.32 , pp. 2399
    • Cho, H.1    Ueda, M.2    Shima, K.3
  • 3
  • 5
    • 0026065919 scopus 로고
    • Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents
    • (1991) J. Med. Chem. , vol.34 , pp. 806
    • Atwal, K.S.1    Swanson, B.N.2    Unger, S.E.3
  • 10
    • 0031544856 scopus 로고    scopus 로고
    • 4-Aryl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione derivatives: Synthesis, enantiomeric separations and in vitro screening as calcium antagonist
    • (1997) Boll. Chim. Farm. , vol.136 , pp. 657
    • Saraç, S.1    Yarim, M.2    Ertan, M.3
  • 11
    • 0031887128 scopus 로고    scopus 로고
    • Synthesis, chemical and pharmacological properties of some 4-aryl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones
    • (1998) Pharmazie , vol.53 , pp. 91
    • Saraç, S.1    Yarim, M.2    Ertan, M.3
  • 12
    • 0035044818 scopus 로고    scopus 로고
    • 4-Aryl-6,6-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones: Synthesis, chromatographic resolution and pharmacological activity
    • (2001) Pharmazie , vol.56 , pp. 298
    • Saraç, S.1    Yarim, M.2    Ertan, M.3
  • 18
    • 0028331505 scopus 로고
    • Resolution by high-performance liquid chromatography using polysaccharide carbamates and benzoates as chiral stationary phases
    • (1994) J. Chromatogr. A , vol.666 , pp. 403
    • Okamoto, Y.1    Kaida, Y.2
  • 19
    • 2042461822 scopus 로고
    • Planar chiral systems. I. Optical resolution of [2.2]paracyclophanes by high-performance liquid chromatography on tris-3,5-dimethyl-phenylcarbamates of cellulose and amylose
    • (1990) Chem. Ber. , vol.841 , pp. 123
    • Hopf, H.1    Grahn, W.2    Barret, D.G.3
  • 20
    • 0024404289 scopus 로고
    • Kalzium-modulatoren vom Typ anellierter dihydropyridine/synthese und pharmakologische wirkung
    • (1989) Arzneim.-Forsch./Drug Res. , vol.39 , Issue.2 , pp. 1393
    • Rose, U.1
  • 21
    • 0025283570 scopus 로고
    • 5-Oxo-1,4-dihydroindenopyridines. Calcium modulators with partial calcium agonistic activity
    • (1990) J. Heterocycl. Chem. , vol.27 , pp. 237
    • Rose, U.1
  • 22
    • 0026557102 scopus 로고
    • Synthesis and pharmacological activities of calcium modulatory hexahydroquinolinones
    • (1991) Heterocycl. Chem. , vol.28 , pp. 2005
    • Rose, U.1
  • 25
    • 0026622987 scopus 로고
    • Synthesis, configuration and calcium modulatory properties of enantiomerically pure 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates
    • (1992) J. Med. Chem. , vol.35 , pp. 2238
    • Rose, U.1    Dräger, M.2
  • 27
    • 0021205586 scopus 로고
    • Calcium antagonists: A class of drugs with a bright future. Part II. Determination of basic pharmacological properties
    • (1984) Life Sci. , vol.35 , pp. 575
    • Spedding, M.1    Cavero, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.