To die or not to die, does it change the function? Behavior of transgenic mice reveals a role for developmental cell death

Brain Research Bulletin

Volumn 57, Issue 1, 2002, Pages 85-91

  Rondi Reig, Laure ^a,b   Mariani, Jean ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b Action (LPPA)   (France)

Author keywords

Bcl 2 gene; Behavior; Developmental cell death; Supernumerary neurons; Transgenic mice

Indexed keywords

PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; APOPTOSIS; ARTICLE; BEHAVIOR; BEHAVIOR DISORDER; BEHAVIORAL SCIENCE; BRAIN REGION; CELL DEATH; DEVELOPMENT; GENE; GENE EXPRESSION; LEARNING; LEARNING DISORDER; MENTAL DISEASE; MOTOR PERFORMANCE; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPSYCHIATRY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; VISION;

ANIMALS; ANXIETY; APOPTOSIS; BRAIN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPERTROPHY; LEARNING DISORDERS; MALE; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MOTOR SKILLS DISORDERS; NERVOUS SYSTEM MALFORMATIONS; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; UP-REGULATION;

EID: 0036146931     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(01)00639-6     Document Type: Article

References (34)

1. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice
2. Can adverse neonatal experiences alter brain development and subsequent behavior?
3. Physiological and induced neuronal death are not affected in NSE-bax transgenic mice
4. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2
5. Matters of life and death in the songbird forebrain
6. Motor deficiency of P53 knock-out mice
7. An animal model of autism; Behavioral studies in the GS guinea-pig
8. The brain in infantile autism; Posterior fossa structures are abnormal
9. What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice
10. Innervation pattern of muscles of one-legged Xenopus laevis supplied by motoneurons from both sides of the spinal cord
11. Reduction in anti-apoptotic protein Bcl-2 in autistic cerebellum
12. Cell death and the creation of regional differences in neuronal numbers
13. Effects of alpha-adrenoreceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behavior
14. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
15. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
16. The use of a plus-maze to measure anxiety in the mouse
17. Programmed cell death; Implications for neuropsychiatric disorders
18. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
19. A promotor that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons
20. Further studies on the development of the isthmo-optic nucleus with special reference to the occurrence and fate of ectopic and ipsilaterally projecting neurons
21. Validation of open-closed arm entries in an elevated plus maze as a measure of anxiety in the rat
22. The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2
23. Vision in mice with neuronal redundancy due to inhibition of developmental cell death
24. Schizophrenia as a development disorder of the cerebral cortex
25. Behavioral and functional analysis of mouse phenotype; SHIRPA, a proposed protocol for comprehensive phenotype assessment
26. Fear decrease in transgenic mice overexpressing bcl-2 in neurons
27. Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilities in a water task
28. Hu-bcl-2 transgenic mice with supernumerary CNS neurons exhibit motor timing impairment
29. Animal spatial cognition
30. The gene knockout technology for the analysis of learning and memory, and neural development
31. Transgenic mice; A decade of progress in technology and research
32. Synaptic plasticity, place cells and spatial memory; Study with second generation knockouts
33. Increased cerebellar Purkinje cell numbers in mice overexpressing a human bcl-2 transgene
34. Increased inferior olivary neuron and cerebellar granule cell numbers in transgenic mice overexpressing the human bcl-2 gene