Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium

Molecular Microbiology

Volumn 27, Issue 6, 1998, Pages 1223-1233

  Mdluli, Khisimuzi ^a   Swanson, John ^a   Fischer, Elizabeth ^a   Lee, Richard E ^a   Barry III, Clifton E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; ISONIAZID; MYCOLIC ACID; PEROXIDASE; RIFAMPICIN;

ARTICLE; ATYPICAL MYCOBACTERIUM; BACTERIAL CELL WALL; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG DESIGN; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; TUBERCULOSIS;

BACTERIAL PROTEINS; CELL DIVISION; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; ISONIAZID; KINETICS; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PERMEABILITY; PEROXIDASES; PHENOTYPE; RIFAMPIN;

EID: 0031907590     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00774.x     Document Type: Article

References (54)

1. Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K.S., Wilson, T., et al. (1994) inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263: 227-230.
2. Barrow, W.W. (1991) Contributing factors of pathogenesis in the Mycobacterium avium complex. Res Microbiol 142: 427-433.
3. Barrow, W.W., and Brennan, P.J. (1982) Isolation in high frequency of rough variants of Mycobacterium intracellulare lacking C-mycoside glycopeptide lipid antigens. J Bacteriol 150: 381-384.
4. Barrow, W.W., Wright, E.L., Goh, K.S., and Rastogi, N. (1993) Activities of fluoroquinolone, macrolide, and aminoglycoside drugs combined with inhibitors of glycosylation and fatty acid and peptide biosynthesis against Mycobacterium avium. Antimicrob Agents Chemother 37: 652-661.
5. Belisle, J.T., Klaczkiewicz, K., Brennan, P.J., Jacobs, Jr, W.R., and Inamine, J.M. (1993) Rough morphological variants of Mycobacterium avium; characterization of genomic deletions resulting in the loss of glycopeptidolipid expression. J Biol Chem 268: 10517-10523.
6. Brennan, P.J., and Nikaido, H. (1995) The envelope of mycobacteria. Annu Rev Biochem 64: 29-63.
7. Chambers, H.F., Moreau, D., Yajko, D., Muck, C., Wagner, C., Hackbarth, C., et al. (1995) Can penicillins and other β-lactam antibiotics be used to treat tuberculosis? Antimicrob Agents Chemother 39: 2620-2624.
8. Chan, I.S.F., Neaton, J.D., Saravolatz, L.D., Crane, L.R., and Osterberger, J. (1995) Frequencies of opportunistic diseases prior to death among HIV-infected persons. AIDS 9: 1145-1151.
9. David, H.L. (1981) Basis for lack of drug susceptibility of atypical mycobacteria. Rev Infect Dis 3: 878-884.
10. David, H.L., Clavel-Seres, S., Clement, F., and Goh, K.-S. (1987) Uptake of selected antibacterial agents in Mycobacterium avium. Zbl Bakt Hyg A 265: 385-392.
11. Etemadi, A.H., and Gasche, J. (1967) Sur l'origine biogenetique du 2-eicosanol et du 2-octadecanol de Mycobacterium avium. Bull Soc Chim Biol 47: 2095-2104.
12. Fauci, A.S. (1984) Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Intern Med 100: 92-106.
13. Green, J.B., Sidhu, G.S., Lewin, S., Levine, J.F., Masur, H., Simberkoff, M.S., et al. (1982) Mycobacterium avium-intracellulare: a case of disseminated life-threatening infection in homosexuals and drug abusers. Ann Intern Med 97: 539-546.
14. Hamid, M.E., Minnikin, D.E., and Goodfellow, M. (1993) A simple chemical test to distinguish mycobacteria from other mycolic-acid-containing actinomycetes. J Gen Microbiol 139: 2203-2213.
15. Heym, B., Honore, N., Truffot-Pernot, C., Banerjee, A., Schurra, Jr, C.W.R.J., Embden, J.D.A.v., et al. (1994) Implications of multidrug resistance for the future of Short-course chemotherapy of tuberculosis: a molecular study. Lancet 344: 293-298.
16. Jarlier, V., and Nikaido, H. (1990) Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J Bacteriol 172: 1418-1423.
17. Johnsson, K., and Schultz, P.G. (1994) Mechanistic studies of the oxidation of isoniazid by the catalase peroxidase from Mycobacterium tuberculosis. J Am Chem Soc 116: 7425-7426.
18. Kazda, J.F. (1983) The principles of the ecology of mycobacteria. In The Biology of the Mycobacteria. Ratledge, C., and Stanford, J. (eds). London: Academic Press, pp. 323-341.
19. Lepper, A.W.D., and Corner, L.A. (1983) Naturally occurring mycobacterioses of animals. In The Biology of the Mycobacteria. Ratledge, C., and Stanford, J. (eds). London: Academic Press, pp. 418-521.
20. Liu, J., Rosenberg, E.Y., and Nikaido, H. (1995) Fluidity of the lipid domain of cell wall from Mycobacterium chelonae. Proc Natl Acad Sci USA 92: 11254-11258.
21. Liu, J., Barry, III, C.E., Besra, G.S., and Nikaido, H. (1996) Mycolic acid structure determines the fluidity of the mycobacterial cell wall. J Biol Chem 271: 29545-29551.
22. Liu, J., Barry, III, C.E., and Nikaido, H. (1998). Cell wall: physical structure and permeability. In Mycobacteria: Molecular Biology and Virulence, Ratledge, C., and Dale, J.W. (eds). Philadelphia, PA: Chapman & Hall, pp. 1-44 (in press).
23. McClatchy, J. (1980) Antituberculosis drugs: mechanism of action, drug resistance, susceptibility testing, and assays of activity in biological fluids. In Antibiotics in Laboratory Medicine. Lorian, V. (ed.). Baltimore: Williams & Wilkins, pp. 135-169.
24. Magliozzo, R.S., and Marcinkeviciene, J.A. (1996) Evidence for isoniazid oxidation by oxyferrous mycobacterial catalase-peroxidase. J Am Chem Soc 118: 11303-11304.
25. Magliozzo, R.S., and Marcinkeviciene, J.A. (1997) The role of Mn (II)-peroxidase activity in mycobacterial catalase-peroxidase in activation of the antibiotic isoniazid. J Biol Chem 272: 8867-8870.
26. Mdluli, K., and Barry, III, C.E. (1996) Drug sensitivity and environmental adaptation of mycobacterial cell wall components. Trends Microbiol 4: 275-281.
27. Mdluli, K., Sherman, D.R., Hickey, M.J., Kreiswirth, B.N., Morris, S., Stover, C.K., and Barry, III, C.E. (1996) Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis. J Infect Dis 174: 1085-1090.
28. Mdluli, K., Zhu, Y., Crane, D.C., and Barry, III, C.E. (1996) The molecular target of activated isoniazid in Mycobacterium tuberculosis. In Proceedings of the 31st US-Japan Tuberculosis Research Conference. Yamada, T. (ed). Nagasaki: US-Japan Cooperative Medical Science Program, pp. 30-34.
29. Middlebrook, G. (1952) Sterilization of tubercle bacilli by isonicotinic acid hydrazide and the incidence of variants resistant to the drug in vitro. Am Rev Tuberc 65: 765-767.
30. Milano, A., Rossi, E.D., Gusberti, L., Heym, B., Marone, P., and Riccardi, G. (1996) The katE gene, which encodes the catalase HPII of Mycobacterium avium. Mol Microbiol 19: 113-123.
31. Minnikin, D.E., Minnikin, S.M., Parlett, J.H., Goodfellow, M., and Magnusson, M. (1984) Mycolic acid patterns of some species of Mycobacterium. Arch Microbiol 139: 225-231.
32. Morris, S., Bai, G.H., Suffys, P., Portillo-Gomez, L., Fairchok, M., and Rouse, D. (1995) Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. J Infect Dis 171: 954-960.
33. Musser, J.M., Kapur, V., Williams, D.L., Kreiswirth, B.N., van Soolingen, D., and van Embden, J.D.A. (1996) Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance. J Infect Dis 173: 196-202.
34. Naik, S.P., Samsonoff, W.A., and Ruck, R.E. (1989) Effects of surface-active agents on drug susceptibility levels and ultrastructure of Mycobacterium avium complex organisms isolated from AIDS patients. Diagn Microbiol Infect Dis 11: 11-19.
35. Rastogi, N., and Goh, K.S. (1990) Action of 1-isonicotinyl-2-palmitoyl hydrazine against the Mycobacterium avium complex and enhancement of its activity by m-Flourophenylalanine. Antimicrob Agents Chemother 34: 2061-2064.
36. Rastogi, N., Frehel, C., Ryter, A., Ohayon, H., Lesourd, M., and David, H.L. (1981) Multiple drug resistance in Mycobacterium avium: is the wall architecture responsible for the exclusion of antimicrobial agents? Antimicrob Agents Chemother 20: 666-677.
37. Rastogi, N., Goh, K.S., and David, H.L. (1990) Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis. Antimicrob Agents Chemother 34: 759-764.
38. Rouse, D.A., DeVito, J.A., Li, Z., Byer, H., and Morris, S.L. (1996) Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance. Mol Microbiol 22: 583-592.
39. Shafran, S.D., Singer, J., Zarowny, D.P., Phillips, P., Salit, I., Walmsley, S.L., et al. (1996) A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin vs. rifampin, ethambutol, clofazamine, and ciprofloxicin. N Engl J Med 335: 377-383.
40. Sherman, D.R., Sabo, P.J., Hickey, M.J., Arain, T.M., Mahairas, G.G., Yuan, Y., et al. (1995) Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria. Proc Natl Acad Sci USA 92: 6625-6629.
41. Sherman, D.R., Mdluli, K., Hickey, M.J., Arain, T.M., Morris, S.L., Barry, III, C.E., et al. (1996) Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis. Science 272: 1641-1643.
42. Stoeckle, M.Y., Guan, L., Riegler, N., Weitzman, I., Kreiswirth, B., Kornblum, J., et al. (1993) Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City. J Infect Dis 168: 1063-1065.
43. Takayama, K., and Davidson, L.A. (1979) Isonicotinic acid hydrazide. In Antibiotics: Mechanism of Action of Antibacterial Agents. Hahn, F.E. (ed.). Berlin: Springer Verlag, pp. 98-119.
44. Takayama, K., Schnoes, H.K., Armstrong, E.L., and Boyle, R.W. (1975) Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis. J Lipid Res 16: 308-317.
45. Thoen, C.O., Himes, E.M., and Karlson, A.G. (1984) Mycobacterium avium complex. In The Mycobacteria: A Sourcebook, Part B. Kubica, G.P., and Wayne, L.G. (eds). New York: Marcel Dekker, pp. 1251-1275.
46. Wayne, L.G., and Diaz, G.A. (1986) A double staining method for differentiating between two classes of mycobacterial catalase in polyacrylamide electrophoresis gels. Anal Biochem 157: 89-92.
47. Winder, F.G. (1982) Mode of action of antimycobacterial agents and associated aspects of the molecular biology of the mycobacteria. In The Biology of the Mycobacteria. Ratledge, C., and Standford, J. (eds). London: Academic Press, pp. 353-438.
48. Youatt, J. (1958) Metabolism of isoniazid by Mycobacterium tuberculosis BCG with reference to current theories of the mode of action. Am Rev Tuberc 78: 806-809.
49. Youatt, J. (1960) The metabolism of isoniazid and other hydrazides by Mycobacteria. Aust J Exp Biol Med Sci 38: 245-250.
50. Youatt, J. (1961) The formation of 4-pyridylmethanol from isonicotinic acid hydrazide (isoniazid) by mycobacteria. Aust J Chem 14: 308-311.
51. Youatt, J. (1962) The metabolism of isoniazid and pyridine aldehydes by Mycobacteria. Aust J Biol Med Sci 40: 191-205.
52. Yuan, Y., Lee, R.E., Besra, G.S., Belisle, J.T., and Barry, III, C.E. (1995) Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 92: 6630-6634.
53. Zhang, Y., Heym, B., Allen, B., Young, D., and Cole, S. (1992) The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 358: 591-593.
54. Zimmmermann, W., and Rosselet, A. (1977) Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics. Antimicrob Agents Chemother 12: 368-372.