Identification of the most relevant factors that affect and reflect the quality of granules by application of canonical and cluster analysis

Journal of Pharmaceutical Sciences

Volumn 91, Issue 1, 2002, Pages 273-281

  Dias, Vitor H ^a   Pinto, João F ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Canonical and cluster analysis; Quality of granules; Relevant factors

Indexed keywords

DRUG; KOLLIDON 120; POVIDONE;

ARTICLE; CLUSTER ANALYSIS; DRUG FORMULATION; DRUG SOLUBILITY; FLOW RATE; PARTICLE SIZE; PORTUGAL;

EID: 0036144849     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10015     Document Type: Article

References (16)

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5. Mechanistic evaluation of binary effects of magnesium stearate and talc as dissolution retardants at 85% drug loading in an experimental extended-release formulation
6. Preliminary investigations in matrix-based tablet formulations of diltiazem hydrochloride containing succinic acid-treated methylcellulose
7. Screening of high shear mixer melt granulation process variables using an asymmetrical factorial design
8. Use of a fractional factorial design to evaluate granulations prepared in a fluidized bed
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11. The development and optimization of tablet formulations using mathematical methods
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13. Relations between two sets of variables
14. Cluster analysis
15. Contribution to the preparation of a directly compressible L-ascorbic acid granular form: Comparison of granules prepared by three granulations methods and evaluation of their corresponding tablets
16. Application of canonical analysis to the evaluation of the influence of changes in components of standard direct compression tablet formulations