Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP

Journal of General Physiology

Volumn 119, Issue 1, 2002, Pages 105-116

  Li, Lehong ^a   Geng, Xuehui ^a   Drain, Peter ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

ADP; ATP; Gating mechanism; Kir6.2; SUR

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL ENERGY; CHANNEL GATING; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MOLECULAR MODEL; NONHUMAN; OOCYTE; PANCREAS ISLET BETA CELL; PATCH CLAMP; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; XENOPUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; FEMALE; ION CHANNEL GATING; LIGANDS; MICE; OOCYTES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; XENOPUS;

EID: 0036142013     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.119.1.105     Document Type: Article

References (43)

1. Cloning of the β-cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
2. Molecular biology of adenosine triphosphate-sensitive potassium channels
3. + channels. Basis for channel opening
4. 2+ ions
5. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
6. Properties of single potassium channels modulated by glucose in rat pancreatic beta-cells
7. ATP channel isoforms
8. Pharmaco-topology of sulfonylurea receptors
9. ATP channel complex
10. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels
11. Fitting and statistical analysis of single-channel records
12. + channels in pancreatic β-cells
13. + channels in pancreatic beta-cells. Spare-channel hypothesis
14. ATP channels
15. Regulation of Shaker K channel inactivation gating by the cAMP-dependent protein kinase
16. ATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit
17. + channels
18. The kinetic and physical basis of K(ATP) channel gating: Toward a unified molecular understanding
19. ATP channel
20. + channel. A molecular probe for the mechanism of ATP-sensitive inhibition
21. + channel in rat pancreatic B-cells
22. ATP channel activation by Mg-ADP and diazoxide
23. ATP channel by interaction with its SUR1 subunit
24. KAPT: An inward rectifier subunit plus the sulfonylurea receptor
25. + channels linked to the green fluorescent protein in human embryonic kidney cells
26. ir6.2 and SUR1 clones
27. ATP channels: Control of nucleotide sensitivity by the N-terminal domain of the subunit
28. ATP channel inhibition by ATP
29. ATP channels
30. Local anaesthetics transiently block currents through single acetylcholine-receptor channels
31. ATP channel kinetics in isolated membrane patches from rat ventricle
32. Adenosine diphosphate as an intracellular regulator of insulin secretion
33. + channels in cardiac muscle
34. + channel revealed with oil-gate concentration jump method
35. ir6.2 subunit
36. Data transformations for improved display and fitting of single-channel dwell time histograms
37. + channels toward intracellular nucleoside diphosphates
38. Molecular analysis of ATP- sensitive K channel gating and implications for channel inhibition by ATP
39. Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches
40. + channels in the absence of the sulphonylurea receptor
41. ATP channel inhibition by ATP
42. + conductance