Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in eskol, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested

Leukemia Research

Volumn 26, Issue 2, 2002, Pages 169-177

  Khalaf, Waleed ^a,b   Maina, Caroline ^a,b   Byers, Joseph ^b   Harvey, William ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EARLHAM COLLEGE   (United States)

Author keywords

Apoptosis; B cell differentiation; Bcl 2; Hairy cell leukemia; IL 6; Interferon ; Oncogenes; TNF ; Vesnarinone

Indexed keywords

ALPHA2B INTERFERON; INTERLEUKIN 6; NUCLEAR PROTEIN; PIPERANOMETOZINE; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; B LYMPHOBLAST; CANCER CELL CULTURE; COMPARATIVE STUDY; CYTOKINE RELEASE; DOWN REGULATION; HAIRY CELL LEUKEMIA; LYMPHOBLASTOID CELL; ONCOGENE C MYC; PRIORITY JOURNAL;

ANTIGENS, NUCLEAR; ANTINEOPLASTIC AGENTS; APOPTOSIS; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, BCL-2; HUMANS; INTERFERON ALFA-2B; INTERLEUKIN-6; LEUKEMIA, HAIRY CELL; NUCLEAR PROTEINS; ONCOGENES; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOLINES; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036140198     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00100-X     Document Type: Article

References (32)

1. Hairy cell leukemia: Characteristics of the neoplastic cells
2. The phenotype of the neoplastic cells of the hairy cell leukemia studied with monoclonal antibodies
3. Characterization of a new cell line (ESKOL) resembling hairy cell leukemia; a model for oncogene regulation and late B-cell differentiation
4. The hairy cell leukemia cell line ESKOL spontaneously synthesizes tumor necrosis factor-alpha and nitric oxide
5. The biological effects of interleukin-6
6. Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B-cell terminal differentiation
7. INK4c and IL-6
8. Interleukin-6 inhibits apoptosis and tumor necrosis factor induced proliferation of B-chronic lymphocytic leukemia
9. Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells
10. Immune functions of tumor necrosis factor
11. Constitutive production of TNF-alpha in hairy cell leukemia: Possible role in the pathogenesis of the cytopenia and effect of treatment with interferon-alpha
12. High level secretion of TNF-alpha contributes to hematopoietic failure in hairy cell leukemia
13. Tumor necrosis factor-alpha, but not lymphotoxin, stimulates growth of tumor cells in hairy cell leukemia
14. Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: Up-regulation of p53 gene expression and induction of apoptosis by TNF-alpha
15. Vesnarinone is a selective inhibitor of macrophage TNF-alpha release
16. On the mechanism of action of interferon-alpha on hairy cell leukemia
17. Interferon-alpha-2b downregulation of oncogenes h-ras, c-raf-2, c-kit, c-myc, c-myb and c-fos in ESKOL, a hairy cell leukemic line, results in temporal perturbation of signal transduction cascade
18. Inadequate production of hematopoietic growth factors in hairy cell leukemia: Up-regulation of IL-6 by recombinant IFN-alpha in vitro
19. Effects of interferon-alpha on autocrine growth factor loops in B lymphoproliferative disorders
20. Autocrine and paracrine regulation of neoplastic cell growth in hairy cell leukemia
21. Autocrine loop of tumor necrosis factor induced by interferon-alpha in tumor cells from hairy cell leukemia
22. Apoptosis in V-myc transformation of myelomonocytic cells and its modulation by CSF-1
23. Transformation by V-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors
24. Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide
25. Interferon-alpha-mediated prevention of in vitro apoptosis of chronic lymphocytic leukemia B cells: Role of bcl-2 and c-myc
26. Interferon-alpha upregulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo
27. Apoptotic cell death induced by c-myc is inhibited by bcl-2
28. Cooperative interaction between c-myc and bcl-2 proto-oncogenes
29. Tumor necrosis factor as an autocrine growth factor for chronic B-cell malignancies
30. Signaling pathway for apoptosis: A racetrack for life or death
31. Regulated commitment of TNF receptor signaling: A molecular switch for death or activation
32. Signal transduction pathways of apoptosis and inflammation induced by the tumor necrosis factor receptor family