Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fcγ receptors

Molecular Immunology

Volumn 38, Issue 7, 2002, Pages 527-538

  Li, Ping ^a   Nagarajan, Shanmugam ^b   Zhu, Cheng ^a   Selvaraj, Periasamy ^b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Cell to cell interactions; Neutrophils; Recombinant Fc receptor

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; LIGAND; RECOMBINANT ANTIBODY; RECOMBINANT ANTIGEN; RECOMBINANT CD16A IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; CELL INTERACTION; CELL SURFACE; CHO CELL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; HUMAN; HUMAN CELL; IMMUNE COMPLEX DISEASE; LIGAND BINDING; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SCATCHARD PLOT; TARGET CELL;

ANIMALS; CELL COMMUNICATION; CROSS-LINKING REAGENTS; DIMERIZATION; HL-60 CELLS; HUMANS; HYBRIDOMAS; IMMUNOGLOBULINS; K562 CELLS; LIGANDS; MICE; MONOCYTES; NEUTROPHILS; RECEPTORS, IGG; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0036139264     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(01)00088-8     Document Type: Article

References (49)

1. Designing CD4 immunoadhesions for AIDS therapy
2. 2+ mobilization and phosphoinositide turnover in human natural killer cells
3. Treatment of refractory immune thrombocytopenic purpura with anti-Fcγ receptor antibody
4. Blockade of clearance of immune complexes by an anti-Fcγ receptor monoclonal antibody
5. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis
6. Cell type-specific glycoforms of Fc gamma RIIIa (CD16): Differential ligand binding
7. Protein and cell membrane iodinations with a sparingly soluble chloramide-1,3,4,6-tetrachloro-3,6-diphenyl glycoluril
8. Soluble Fcγ receptors
9. Affinity of the interaction between Fc gamma receptor type III (FcγRIII) and monomeric human IgG subclasses. Role of FcγRIII glycosylation
10. Recombinant soluble FcγRII inhibits immune complex precipitation
11. The two binding-site models of human IgG binding Fc gamma receptors
12. Binding characteristics and isotype specificity of Fc receptors on K cells
13. CD23: A multi-functional receptor/lymphokine?
14. The effect of hypotonicity, glutamine, and glycine on red cell preservation
15. Pathogenesis of dengue: Challenges to molecular biology
16. Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice
17. Autoregulatory circuits in myeloma tumor cell cytotoxicity mediated by soluble CD16
18. The PI-linked receptor FcRIII is released on stimulation of neutrophils
19. Binding characteristics of dimeric IgG subclass complexes to human neutrophils
20. Soluble Fcγ receptor III in human plasma originates from release by neutrophils
21. Molecular basis of Fc receptor function
22. The glycosylphosphatidylinositol-linked Fcγ receptor III represents the dominant receptor structure for immune complex activation of neutrophils
23. Recombinant soluble human Fc-gamma-RII: Production, characterization, and inhibition of the Arthus reaction
24. Molecular definition of interaction sites on human IgG for Fc receptors (huFc gamma R)
25. Two distinct classes of IgG Fc receptors on a human monocyte line (U937) defined by differences in binding of murine IgG subclasses at low ionic strength
26. Receptors for immunoglobulin G. Molecular diversity and implications for disease
27. Membrane anchoring and spontaneous release of CD16 (FcR III) by natural killer cells and granulocytes
28. Functional interactions of aglycosylated monoclonal anti-D with FcγRI+ and FcγRIII+ cells
29. Binding of the B-cell activation antigen B7 to CD28 costimulates T-cell proliferation and interleukin 2 mRNA accumulation
30. Immunosuppression in vivo by a soluble form of the CTLA-4 T-cell activation molecule
31. A protein structural change in aglycosylated IgG3 correlates with loss of huFc gamma R1 and huFc gamma R111 binding and/or activation
32. Fc receptor triggering induces expression of surface activation antigens and release of platele-activating factor in large granular lymphocytes
33. Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules
34. Construction, purification and functional reconstitution on tumor cells of glycolipid-anchored human B7-1 (CD80)
35. Ligand binding and phagocytosis by CD16 (Fc gamma receptor III) isoforms
36. Cell specific, activation dependent regulation of neutrophil CD32A ligand binding function
37. Immune thrombocytopenia and Fc receptor-mediated phagocyte function
38. On the interaction of IgG subclasses with the low affinity FcgammaIIa (CD32) on human monocytes, neutrophils, and platlets
39. Flow cytometric quantitation of attachment and phagocytosis in phenotypically-defined subpopulations of cells using PKH26-labeled Fc gamma R-specific probes
40. Fc receptors
41. An alternative Fc gamma-receptor ligand: Potential role in T-cell development
42. The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal hemoglobinuria
43. Natural killer cell and granulocyte FcγRIII (CD16) differ in membrane anchor and signal transduction
44. Biologic response to anti-CD16 monoclonal antibody therapy in the human immunodeficiency virus-related immune thrombocytopenic purpura patient
45. An FcγRIII (CD16)-specific autoantibody from a patient with progressive systemic sclerosis
46. FcR gamma chain deletion results in pleiotrophic effector cell defects
47. Structure and function of human and murine receptors for IgG
48. Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing FcγRI and or FcγRII receptors
49. Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimera