The phosphatidylinositol-phospholipase C from Trypanosoma cruzi is active on inositolphosphoceramide

Molecular and Biochemical Parasitology

Volumn 119, Issue 1, 2002, Pages 131-133

  Salto, María Laura ^a   Furuya, Tetsuya ^b   Moreno, Silvia N ^b   Docampo, Roberto ^b   De Lederkremer, Rosa M ^a  

^a DEPARTAMENTO DE QUÍMICA ORGÁNICA   (Argentina)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Inositolphosphoceramide; PI PLC; Trypanosoma cruzi

Indexed keywords

INOSITOL DERIVATIVE; INOSITOLPHOSPHOCERAMIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; EPIMASTIGOTE; NONHUMAN; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; TRYPANOSOMA CRUZI;

ANIMALS; CLONING, MOLECULAR; GLYCOSPHINGOLIPIDS; HYDROLYSIS; KINETICS; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0036139029     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(01)00392-9     Document Type: Article

References (15)

1. A novel phophatidylinositol-phopholipase C in Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation
2. Developmentally regulated expression of ceramide in Trypanosoma cruzi
3. Structural analysis of inositol phospholipids from Trypanosoma cruzi epimastigote forms
4. Structural features of the lipopeptidophosphoglycan from Trypanosoma cruzi common with the glycophosphatidylinositol anchors
5. The lipid structure of the glycosylphosphatidylinositol-anchored mucin-like sialic acid acceptors of Trypanosoma cruzi changes during parasite differentiation from epimastigotes to infective metacyclic trypomastigote forms
6. The trans-sialidase of Trypanosoma cruzi is anchored by two different lipids
7. Structure of the glycosylphosphatidylinositol-anchor of the trans-sialidase from Trypanosoma cruzi metacyclic trypomastigote forms
8. Evidence for phospholipases from Trypanosoma cruzi active on phosphatidylinositol and inositolphosphoceramide
9. The sphingomyelin cycle and the second messenger function of ceramide
10. Lipids and the modulation of cell function
11. Identification of ISC1 (YERO19w) as inositolphophosphingolipid-phospholipase C in Saccharomyces cerevisiae
12. Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae
13. Structural studies on a lipoarabinogalactan of Crithidia fasciculata
14. Phosphatidylinositol-specific phospholipase C (PI-PLC) cleavage of GPI-anchored surface molecules of Trypanosoma cruzi triggers in vitro morphological reorganization of trypomastigotes
15. Conservation of genetic linkage between heat shock protein 100 and glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei and Trypanosoma cruzi