Gadolinium neutron-capture therapy using novel gadopentetic acid- chitosan complex nanoparticles: In vivo growth suppression of experimental melanoma solid tumor

Cancer Letters

Volumn 150, Issue 2, 2000, Pages 177-182

  Tokumitsu, Hiroyuki ^a   Hiratsuka, Junichi ^b   Sakurai, Yoshinori ^c   Kobayashi, Tooru ^c   Ichikawa, Hideki ^a   Fukumori, Yoshinobu ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Chitosan; Gadolinium; Gadopentetic acid; Nanoparticle; Neutron capture therapy

Indexed keywords

CHITOSAN; GADOLINIUM PENTETATE; NANOPARTICLE;

ANIMAL MODEL; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; MALE; MELANOMA; MOUSE; NEUTRON CAPTURE THERAPY; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; SOLID TUMOR; TUMOR GROWTH;

ANIMALS; CHITIN; CHITOSAN; GADOLINIUM DTPA; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NEUTRON CAPTURE THERAPY;

ANIMALIA;

EID: 0033995220     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00388-2     Document Type: Article

References (20)

1. 157Gd. Nucl. Phys. A. 304:1978;327-428.
2. Locher G.L. Biological effects and therapeutic possibilities of neutron. Am. J. Roentgenol. Radium Ther. 36:1936;1-13.
3. Barth R.F., Soloway A.H. Boron neutron capture therapy of primary and metastatic brain tumors. Mol. Chem. Neuropathol. 21:1994;139-154.
4. 10B molecule-malanoma cell interaction from in vitro to first clinical trial. Pigment Cell Res. 2:1989;226-234.
5. Garber D.I., Kinsey R.R. Neutron Cross Sections Report, BNL-325. 3rd Edition :1976;Brookhaven National Laboratory, New York.
6. Brugger R.M., Shih, J.A. Evaluation of gadolinium-157 as a neutron capture therapy agent. Strahlenther. Onkol. 165:1989;153-156.
7. 157Gd. Int. J. Radiat. Biol. 54:1988;205-208.
8. Hofmann B., Fischer C.-O., Lawaczeck R., Platzek J., Semmler W. Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent Gadobutrol. Invest. Radiol. 34:1999;126-133.
9. Khokhlov V.F., Yashkin P.N., Silin D.I., Djorova E.S., Lawaczeck R. Neutron capture therapy with Gd-DTPA in tumor-bearing rats. Mishima Y. Cancer Neutron Capture Therapy. 1996;865-869 Plenum Press, New York.
10. Akine Y., Tokita N., Tokuuye K., Satoh M., Churei H., Pechoux C.L., Kobayashi T., Kanda K. Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy. Jpn. J. Cancer Res. 84:1993;841-843.
11. Akine Y., Tokita N., Tokuuye K., Satoh M., Kobayashi T., Kanda K. Electron-equivalent dose for the effect of gadolinium neutron capture therapy on the growth of subcutaneously-inoculated Ehrlich tumor cells in mice. Jpn. J. Clin. Oncol. 23:1993;145-148.
12. Matsumoto T. Transport calculations of depth-dose distributions for gadolinium neutron capture therapy. Phys. Med. Biol. 37:1992;155-162.
13. Leroux J.-C., Allémann E., De Jaeghere F., Doelker E., Gurny R. Biodegradable nanoparticles - From sustained release formulations to improved site specific drug delivery. J. Control. Release. 39:1996;339-350.
14. Gref R., Minamitake Y., Peracchia M.T., Trubetskoy V., Torchilin V., Langer R. Biodegradable long-circulating polymeric nanospheres. Science. 263:1994;1600-1603.
15. Chitin and Chitosan: Sources, Chemistry, Biochemistry, Physical Properties and Applications. Skjask-Braek G., Anthonsen T., Sandford P. 1989;Elsevier Applied Science, London.
16. Felt O., Buri P., Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev. Ind. Pharm. 24:1998;979-993.
17. Tokumitsu H., Ichikawa H., Fukumori Y. Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization. Pharm. Res. 16:1999;1830-1835.
18. Ichihashi M., Sasase A., Hiramoto T., Funasaka Y., Hatta S., Mishima Y., Kobayashi T., Fukuda H., Yoshino K. Relative biological effectiveness (RBE) of thermal neutron capture therapy of cultured B-16 melanoma cells preincubated with 10B-paraboronophenylalanine. Pigment Cell Res. 2:1989;325-329.
19. 10B-neutron capture therapy for early skin reaction in the hamster. Radiat. Res. 128:1991;186-191.
20. Kobayashi T., Kanda K., Fujita Y., Sakurai Y., Ono K. The upgrade of the heavy water facility of the Kyoto University Reactor for neutron capture therapy. Larsson B. Advances in Neutron Capture Therapy. Vol.1. 1997;321-325 Elsevier Science, Amsterdam.