Production of human clotting Factor IX without toxicity in mice after vascular delivery of a lentiviral vector

Nature Biotechnology

Volumn 20, Issue 1, 2002, Pages 53-57

  Tsui, L V ^a   Kelly, M ^a   Zayek, N ^a   Rojas, V ^a   Ho, K ^a   Ge, Y ^a   Moskalenko, M ^a   Mondesire, J ^a   Davis, J ^a   Van Roey, M ^a   Dull, T ^a   McArthur, J G ^a  

^a CELL GENESYS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CELLS; PROTEINS; TOXICITY; VIRUSES;

LENTIVIRAL VECTORS;

GENE TRANSFER;

RECOMBINANT BLOOD CLOTTING FACTOR 9; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; DRUG MANUFACTURE; GENE TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS; IN VIVO STUDY; LENTIVIRINAE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SAFETY; TOXICITY;

ANIMALS; BROMODEOXYURIDINE; CELL DIVISION; FACTOR IX; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; KINETICS; LENTIVIRUS; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, NUDE; SPLEEN; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSGENES; VIRAL ENVELOPE PROTEINS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRUS; RNA VIRUSES;

EID: 0036137639     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0102-53     Document Type: Article

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