PrPSc is not detected in peripheral blood leukocytes of scrapie-infected sheep: Determining the limit of sensitivity by immunohistochemistry

Clinical and Diagnostic Laboratory Immunology

Volumn 9, Issue 2, 2002, Pages 499-502

  Herrmann, Lynn M ^a   Baszler, Timothy V ^a   Knowles, Donald P ^a   Cheevers, William P ^a  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; LYMPH NODE CELL; NONHUMAN; PRIORITY JOURNAL; SCRAPIE; SHEEP;

ANIMALS; ANTIBODIES, MONOCLONAL; IMMUNOHISTOCHEMISTRY; LEUKOCYTES; PRPSC PROTEINS; SCRAPIE; SENSITIVITY AND SPECIFICITY; SHEEP;

EID: 0036131125     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.9.2.499-502.2002     Document Type: Article

References (14)

1. Identification of a protein that purifies with the scrapie prion
2. Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans
3. Pathogenesis of scrapie virus infection in the mouse
4. Binding of disease-associated prion protein to plasminogen
5. Natural infection of Suffolk sheep with scrapie virus
6. Distribution of prion protein in the ileal Peyer's patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent
7. Cellular prion protein is expressed on peripheral blood mononuclear cells but not platelets of normal and scrapie-infected sheep
8. Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep
9. Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy
10. Sc in nictitating membrane lymphoid tissue of sheep
11. Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue
12. Use of capillary electrophoresis and fluorescent labeled peptides to detect the abnormal prion protein in the blood of animals that are infected with a transmissible spongiform encephalopathy
13. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie
14. Scrapie-associated prio-protein in the gastrointestinal tract of sheep with natural scrapie