New tools for the construction of replication-competent adenoviral vectors with altered E1A regulation

Journal of Virological Methods

Volumn 103, Issue 1, 2002, Pages 41-49

  Avvakumov, Nikita ^a   Mymryk, Joe S ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Adenoviral vectors; Conditionally replicating adenovirus; E1A Regulation

Indexed keywords

ADENOVIRUS VECTOR; DEXAMETHASONE; GLUCOCORTICOID; RESTRICTION ENDONUCLEASE;

ARTICLE; CELL TYPE; CONTROLLED STUDY; GENE CASSETTE; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION MAPPING; TARGET CELL; TRANSCRIPTION REGULATION; VIRAL GENETICS; VIROGENESIS; VIRUS RECOMBINANT; VIRUS REPLICATION;

ADENOVIRUS E1A PROTEINS; ADENOVIRUSES, HUMAN; CYTOMEGALOVIRUS; DEFECTIVE VIRUSES; DEXAMETHASONE; DNA REPLICATION; DNA, RECOMBINANT; DNA, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HUMANS; KB CELLS; MAMMARY TUMOR VIRUS, MOUSE; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); VIRUS CULTIVATION; VIRUS REPLICATION;

ADENOVIRIDAE; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MOUSE MAMMARY TUMOR VIRUS;

EID: 0036129366     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-0934(01)00440-2     Document Type: Article

References (33)

1. Replicative adenoviruses for cancer therapy
2. Adenovirus E1A proteins and transformation
3. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
4. Transformation by human adenoviruses
5. Cooperative binding of EF-1A to the E1A enhancer region mediates synergistic effects on E1A transcription during adenovirus infection
6. Multifunctional yeast high-copy-number shuttle vectors
7. The development of conditionally replicative adenoviruses for cancer therapy
8. Propagation in a fluid medium of a human epidermoid carcinoma, strain KB
9. Characterization of a human cell line transformed by DNA from human adenovirus type 5
10. A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma
11. Monoclonal antibodies specific for adenovirus early region 1A proteins: Extensive heterogeneity in early region 1A products
12. The adenovirus type 5 E1A enhancer contains two functionally distinct domains: One is specific for E1A and the other modulates all early units in cis
13. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
14. An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy
15. Adenovirus E1A under the control of heterologous promoters: Wide variation in E1A expression levels has little effect on virus replication
16. Evaluation of E1-mutant adenoviruses as conditionally replicating agents for cancer therapy
17. An adenovirus type 5 early gene function regulates expression of other early viral genes
18. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
19. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
20. Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen
21. Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells
22. Tn5 mutagenesis of the transforming genes of human adenovirus type 5
23. Cyclic AMP signaling is required for function of the N-terminal and CR1 domains of adenovirus E1A in Saccharomyces cerevisiae
24. Structure of adenovirus chromatin
25. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor
26. Tumour suppressive properties of the adenovirus 5 E1A oncogene
27. Influence of the adenovirus 5 E1A oncogene on chromatin remodeling
28. The TATA homology and the mRNA 5′ untranslated sequence are not required for expression of essential adenovirus E1A functions
29. Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
30. Adenoviral vectors for cancer gene therapy
31. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription
32. Insulation of a conditionally expressed transgene in an adenoviral vector
33. Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy