Chemoprevention of N-methylnitrosourea-induced colon carcinogenesis by ursodeoxycholic acid-5-aminosalicylic acid conjugate in F344 rats

Japanese Journal of Cancer Research

Volumn 93, Issue 2, 2002, Pages 143-150

  Narisawa, Tomio ^a   Fukaura, Yoko ^a   Takeba, Naomi ^b   Nakai, Keiko ^b  

^a AKITA UNIVERSITY   (Japan)

^b Toxicology Laboratory   (Japan)

Author keywords

Aminosalicylic acid; Chemoprevention; Colon cancer; Ursodeoxycholic acid; Ursodeoxycholic acid 5 aminosalicylic acid conjugate

Indexed keywords

BILE ACID; MESALAZINE; METHYLNITROSOUREA; NONSTEROID ANTIINFLAMMATORY AGENT; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CANCER INHIBITION; CHEMOPROPHYLAXIS; COLON ADENOCARCINOMA; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE MODEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG FECES LEVEL; DRUG STRUCTURE; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SUBMUCOSA; TEST MEAL; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; TUMOR PROMOTION; TUMOR VOLUME;

ANIMALS; ANTICARCINOGENIC AGENTS; BILE ACIDS AND SALTS; COLONIC NEOPLASMS; FEMALE; MESALAMINE; METHYLNITROSOUREA; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; URSODEOXYCHOLIC ACID;

EID: 0036124911     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2002.tb01252.x     Document Type: Article

References (33)

1. Causes, relevant mechanisms, and prevention of large bowel cancer
2. "Food, Nutrition and the Prevention of Cancer: A Global Perspective"
3. Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats
4. Promoting effect of bile acids in colon carcinogenesis in germfree and conventional F344 rats
5. Effect of dietary administration of chenodeoxycholic acid on N-methyl-N-nitrosourea-induced colon cancer in rats
6. Effect of cholic acid feeding on N-methyl-N-nitrosourea-induced colon tumors in rats
7. Chemoprevention of azoxymethane-induced colon carcinogenesis by supplemental dietary ursodeoxycholic acid
8. Prevention of N-methylnitrosourea-induced colon tumorigenesis by ursodeoxycholic acid in F344 rats
9. Cyclooxygenase-2 inhibitors in tumorigenesis (Part II)
10. Aspirin and other nonsteroidal anti-inflammatory drugs and colorectal neoplasia
11. Synthesis and intestinal metabolism of ursodeoxycholic acid conjugate with an anti-inflammatory agent, 5-aminosalicylic acid
12. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
13. High-performance liquid chromatographic determination of free and conjugated bile acids in serum, liver biopsies, bile, gastric juice and feces by fluorescence labeling
14. Simultaneous determination of bile acids in rat bile and serum by high-performance liquid chromatography
15. Disposition of 5-aminosalicylic acid by 5-aminosalicylic acid-delivering compounds
16. Effects of dietary bile acids on formation of azoxymethane-induced aberrant crypt foci in F344 rats
17. Chemopreventive effects of 6-fluoroursode-oxycholic acid on azoxymethane-induced aberrant crypt foci in rat colon
18. The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: Suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue
19. Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats
20. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression
21. Basic studies on 5-(7-hydroxy-3-O-phosphonocolyl)aminosalicylic acid for the evaluation of microbial overgrowth
22. Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps
23. The effect of ursodeoxycholic and lithocholic acid on cell cycle and apoptosis in human colon adenocarcinoma cells
24. Ursodeoxycholate, a chemopreventive bile salt in colon carcinogenesis, stimulates, apoptosis and inhibits Bcl-2 expression in Caco cells
25. Modulation of colonic xenobiotic metabolizing enzymes by feeding bile acids: Comparative effects of cholic, deoxycholic, lithocholic and ursodeoxycholic acids
26. Mechanism of action of chemopreventive ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: Potential role of protein kinase C-α, βII, and -ζ
27. Stimulation of ornithine decarboxylase activity and DNA synthesis by phorbol esters or bile acids in rat colon
28. Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon
29. The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethyl-hydrazine rat model
30. Sulfasalazine alters the character of dimethylhydrazine-induced colorectal carcinoma in rats
31. Actions of sulfasalazine and 5-aminosalicylic acid as reactive oxygen scavengers in the suppression of bile acid-induced increases in colonic epithelial cell lose and proliferative activity
32. Modulation of base hydroxylation by bile acids and salicylate in a model of human colonic mucosal DNA: Putative implications in colonic cancer
33. Risk factors for colorectal cancer in patients with ulcerative colitis: A case-control study