Delays in insulin signaling towards glucose disposal in human skeletal muscle

Journal of Endocrinology

Volumn 172, Issue 3, 2002, Pages 645-651

  Grimmsmann, T ^a   Levin, K ^a   Meyer, M M ^a   Beck Nielsen, H ^a   Klein, H H ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; NEUTRAL INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; MALE; MUSCLE BIOPSY; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN SYNTHASE; HUMANS; INSULIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; THORIUM; TIME FACTORS;

EID: 0036120053     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1720645     Document Type: Article

References (30)

1. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research
2. Functional and structural differences in human and rat-derived insulin receptors: Characterization of the β-subunit kinase activity
3. Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men
4. Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: Identification of multiple cellular defects in glucose transport
5. In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies
6. Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle
7. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
8. Labelled glucose infusate technique in clamp studies. Is precise matching of glucose specific activity important?
9. Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid
10. Processing of insulin by bovine endothelial cells in culture
11. Receptor-mediated transport of insulin across endothelial cells
12. Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes
13. A microtiter well assay system to measure insulin activation of insulin receptor kinase in intact human mononuclear cells
14. Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM
15. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
16. Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity
17. Estimation of total body water by bioelectrical impedance analysis
18. Effects of arterial versus venous sampling on analysis of glucose kinetics in man
19. Decreased activation rate of insulin-stimulated glucose transport in adipocytes from obese subjects
20. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity
21. In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
22. Diffusion of glucose, insulin, inulin, and Evans blue protein into thoracic duct lymph of man
23. Muscle fiber type specificity in insulin signal transduction
24. Influence of glucose loading and of injected insulin on hepatic glucose output
25. The insulin signaling pathway
26. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
27. Insulin signaling in human skeletal muscle - Time course and effect of exercise
28. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
29. Insulin transport across capillaries is rate limiting for insulin action in dogs
30. Insulin action and insulin resistance in human skeletal muscle