Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: Correlation between cognitive impairment and plasma drug concentration

British Journal of Clinical Pharmacology

Volumn 53, Issue 3, 2002, Pages 296-304

  Tagawa, Masaaki ^a   Kano, Michiko ^a   Okamura, Nobuyuki ^a   Higuchi, Makoto ^a   Matsuda, Michiaki ^c   Mizuki, Yasuyuki ^c   Arai, Hiroyuki ^a   Fujii, Toshihiko ^c   Komemushi, Sadao ^d   Itoh, Masatoshi ^b   Sasaki, Hidetada ^a   Watanabe, Takehiko ^a   Yanai, Kazuhiko ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d KINKI UNIVERSITY   (Japan)

Author keywords

(+) Chlorpheniramine; Cognition; Ebastine; Plasma concentration; Tachistoscope

Indexed keywords

CAREBASTINE; CHLORPHENIRAMINE; EBASTINE; PLACEBO;

ACCURACY; ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REACTION TIME; SEDATION; SOMNOLENCE; TASK PERFORMANCE; VISUAL DISCRIMINATION;

ADMINISTRATION, ORAL; ADULT; BUTYROPHENONES; CHLORPHENIRAMINE; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE H1 ANTAGONISTS; HUMANS; MALE; PIPERIDINES; REACTION TIME; SLEEP; STEREOISOMERISM; VISUAL PERCEPTION;

EID: 0036119715     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01183.x     Document Type: Article

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