Sedative effects of antihistamines: Safety, performance, learning, and quality of life

Clinical Therapeutics

Volumn 19, Issue 1, 1997, Pages 39-55

  Nolen, Thomas M ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Columbiana Associates ^*  (United States)

Author keywords

antihistamines; learning; performance; quality of life; safety; sedation

Indexed keywords

ALCOHOL; ANTIHISTAMINIC AGENT; ASTEMIZOLE; BROMPHENIRAMINE; CETIRIZINE; CHLORPHENIRAMINE; CLARITHROMYCIN; CLEMASTINE; DIPHENHYDRAMINE; DISOPYRAMIDE; ERYTHROMYCIN; FEXOFENADINE; FLAVONOID; HALOPERIDOL; HYDROXYZINE; LORATADINE; PENTAMIDINE; PHENINDAMINE; PROBUCOL; PROCAINAMIDE; PROMETHAZINE; QUINIDINE; SEDATIVE AGENT; SOTALOL; TERFENADINE; THIORIDAZINE; TRIPELENNAMINE; TRIPROLIDINE; UNINDEXED DRUG;

ALLERGIC RHINITIS; ASTHMA; BLOOD BRAIN BARRIER; CAR DRIVING; CLINICAL TRIAL; DRUG CLASSIFICATION; FOOD AND DRUG ADMINISTRATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; LEARNING; OTITIS MEDIA; PATIENT SATISFACTION; PERENNIAL RHINITIS; PSYCHOMOTOR DISORDER; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; REVIEW; SEDATION; SINUSITIS; TORSADE DES POINTES; URTICARIA;

EID: 0030894778     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(97)80071-9     Document Type: Article

References (63)

1. Marshall PS, Eduardo A. Effects of allergy season on mood and cognitive function. Ann Allergy. 1993;71:251-258.
2. McMenamin P. Costs of hay fever in the United States in 1990. Ann Allergy. 1994; 73:35-39.
3. Hess A, Lyon D. Allergic rhinitis - A major study of the habits and attitudes of consumers. Presented at the 41st Annual Meeting of the American Academy of Allergy and Immunology; March 16-20, 1985: New York, NY J Allergy Clin Immunol. 1985;75(Suppl):200. Abstract 381A.
4. Public use data tape documentation. 1985 National Ambulatory Medical Care Survey. Hyattsville, Md: National Center for Health Statistics; 1987.
5. Baraniuk JN, Meltzer EO, Spector SL. Impact of allergic rhinitis and related airway disorders. J Respir Dis. 1996;17 (Suppl):511-523.
6. Ross RN. The costs of allergic rhinitis. Am J Managed Care. 1996;II:285-290.
7. Kalivas J, Breneman D, Tharp M, et al. Urticaria: Clinical efficacy of cetirizine in comparison with hydroxyzine and placebo. J Allergy Clin Immunol. 1990;86: 1014-1018.
8. McEvoy GK, ed. AHFS Drug Information 1992. Bethesda, Md: American Society of Hospital Pharmacists; 1992:2-5.
9. 1-receptor antagonists. Ann Allergy. 1991;66:5-21.
10. Meltzer EO. Performance effects of antihistamines. J Allergy Clin Immunol. 1990; 86:613-619.
11. Kemp JP, Buckley CE, Gershwin ME. Multicenter, double-blind, placebo-controlled trial of terfenadine in seasonal allergic rhinitis and conjunctivitis. Ann Allergy. 1985;54:502-509.
12. 1-antagonist. Am J Rhinol. 1987;1:95-99.
13. Roman IR. Loratadine - clinical profile. Presented at the European Academy of Allergology and Clinical Immunology; May 1986; Budapest, Hungary. Abstract.
14. Dockhorn RJ, Bergner A, Connell JT, et al. Safety and efficacy of loratadine (SCH 29851), a new nonsedating antihistamine in seasonal allergic rhinitis. Ann Allergy. 1987;58:407-411.
15. Gutkowski A, Shulz JI, Herbert J, et al. Efficacy of loratadine 10 mg OD vs terfenadine 60 mg BID and placebo in patients with seasonal allergic rhinitis. Presented at the European Academy of Allergology and Clinical Immunology; May 1986; Budapest, Hungary. Abstract.
16. Pedrali P, Bruttmann G. Efficacy of loratadine in the management of idiopathic chronic urticaria. Presented at the European Academy of Allergology and Clinical Immunology; May 1986; Budapest, Hungary. Abstract.
17. Roehrs T, Tietz EI, Zorick FJ, Roth T. Daytime sleepiness and antihistamines. Sleep. 1984;7:137-141.
18. Parrott AC, Hindmarch I. The Leeds Sleep Evaluation Questionnaire in psychophar-macological investigations - A review. Psychopharmacology. 1980;71:173-179.
19. Adam K, Oswald I. The hypnotic effects of an antihistamine: Promethazine. Br J Clin Pharmacol. 1986;22:715-717.
20. Druce H. Impairment of function by antihistamines. Ann Allergy. 1990;64: 403-405.
21. Roth T, Roehrs T, Koshorek G, et al. Sedative effects of antihistamines. J Allergy Clin Immunol. 1987;80:94-98.
22. Meador KJ, Loring DW, Thompson EE, Thompson WO. Differential cognitive effects of terfenadine and chlorpheniramine. J Allergy Clin Immunol. 1989;84: 322-325.
23. 1-receptor antagonists) terfenadine and chlorpheniramine in children. J Pediatr. 1994;124:979-983.
24. Gengo FM, Gabos C. Antihistamines, drowsiness, and psychomotor impairment: Central nervous system effect of cetirizine. Ann Allergy. 1987;59:53-57.
25. Nicholson AN, Smith PA, Spencer MB. Antihistamines and visual function: Studies on dynamic acuity and the pupillary response to light. Br J Clin Pharmacol. 1982;14:683-690.
26. Clarke CH, Nicholson AN. Performance studies with antihistamines. Br J Clin Pharmacol. 1978;6:31-35.
27. Hindmarch I, Bhatti JZ. Psychomotor effects of astemizole and chlorpheniramine, alone and in combination with alcohol, Int Clin Psychopharmacol. 1987;2:117-119.
28. O'Hanlon JF. Antihistamines and driving performance: The Netherlands. J Respir Dis. 1988;9:12-17.
29. Falliers CJ, Brandon ML, Buchman E, et al. Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis. Ann Allergy. 1991;66:257-262.
30. DuBuske L. Dose-ranging comparative evaluation of cetirizine in patients with seasonal allergic rhinitis. Ann Allergy. 1995;74:345-354.
31. Nicholson AN, Stone BM. Antihistamines: Impaired performance and tendency to sleep. Eur J Clin Pharmacol. 1986;30: 27-32.
32. Warren R, Simpson H, Hilchie J, et al. Drugs detected in fatally injured drivers in the province of Ontario. In: Goldberg L, ed. Alcohol, Drugs, and Traffic Safety. Vol. 1. Stockholm: Almquist and Wiksell; 1981:203-217.
33. Aso T, Sakai Y. Effects of terfenadine on actual driving performance. Jpn J Pharmacol Ther. 1988;19:681-688.
34. Volkerts ER, van Willigenburg PP, van Laar MW, Maes RAA. Does cetirizine belong to the new generation of antihistamines? An investigation into its acute and subchronic effects on highway driving, psychometric test performance and daytime sleepiness. Hum Psychopharmacol. 1992;7:227-238.
35. Ramaekers JG, Uiterwijk MMC, O'Hanlon JF. Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving. Eur J Clin Pharmacol. 1992;42:363-369.
36. US Department of Transportation Digest of State Alcohol-Highway Safety Related Legislation. 14th ed. United States Department of Transportation; 1996.
37. Vuurman EFPM, van Veggel LMA, Uiterwijk MMC, et al. Seasonal allergic rhinitis and antihistamine effects on children's learning. Ann Allergy. 1993;71:121-126.
38. Seidel WF, Cohen S, Bliwise NG, Dement WC. Cetirizine effects on objective measures of daytime sleepiness and performance. Ann Allergy. 1987;59:58-62.
39. Vollmer R, Matejcek M, Greenwood C, et al. Correlation between EEG changes indicative of sedation and subjective responses. Neuropsychobiology. 1983;10: 249-253.
40. Goetz DW, Jacobson JM, Apaliski SJ, et al. Objective antihistamine side effects are mitigated by evening dosing of hydroxyzine. Ann Allergy. 1991;67:448-454.
41. Nicholson AN. The significance of impaired performance. Int Clin Pharmacol. 1988;3:117-127.
42. Schweitzer PK, Muehibach MJ, Walsh JK. Sleepiness and performance during threeday administration of cetirizine or diphenhydramine. J Allergy Clin Immunol. 1994; 94:716-724.
43. Thach BT, Chase TN, Bosma JF. Oral facial dyskinesia associated with prolonged use of antihistaminic decongestants. NEJM. 1975;293:486-487.
44. Wyngaarden JF, Seevers MH. The toxic effects of antihistaminic drugs. JAMA. 1951;145:277-282.
45. King G, Weeks SD. Pyribenzamine activation of the electroencephalogram. Electroencephalogr Clin Neurophysiol. 1965; 18:503-507.
46. Koppel C, Ibe K, Tenczer J. Clinical symptomatology of diphenhydramine overdose: An evaluation of 136 cases in 1982 to 1985. J Toxicol Clin Toxicol. 1987;25: 53-70.
47. Murri L, Massetani R, Krause M, et al. Evaluation of antihistamine-related daytime sleepiness. J Allergy Clin Immunol. 1991;47:532-534.
48. Herman D, Arnaud A, Dry J, et al. Efficacité clinique et tolérance de la loratadine versus cétirizine dans le traitment de la rhinite allergique saisonnière. Allerg Immunol. 1992;24:270-274.
49. Backhouse CI, Renton R. Fidler C, Rosenberg RM. Multicentre, double-blind comparison of terfenadine and cetirizine in patients with seasonal allergic rhinitis. Br J Clin Pharmacol. 1990;44:88-91.
50. Offenloch K, Zahner G. Rated performance, cardiovascular and quantitative EEG parameters during simulated instrument flight under the effect of terfenadine. Arzneim-Forsch Drug Res. 1992;42: 864-868.
51. Neves-Pinto RM, Moreira Lima G, da Mota Teixeira R. A double-blind study of the effects of loratadine versus placebo on the performance of pilots. Am J Rhinol. 1992;5:23-27.
52. New antihistamines not approved for flying. Federal Air Surgeon's Medical Bulletin. Summer 1996:16.
53. Moser L, Hüther KJ, Koch-Weser J, Lundt PV. Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. Eur J Clin Pharmacol. 1978;14:417-423.
54. Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA. 1993;269:1532-1536.
55. Nightingale SL. Warnings issued on nonsedating antihistamines terfenadine and astemizole. JAMA. 1992;268:705.
56. Honig PK, Wortham DC, Zamani K, Cantilena LR. Comparison of the effect of the macrolide antibiotics erythromycin, darithromycin and azithromycin on terfenadine steady-state pharmacokinetics and electrocardiographic parameters. Drug Invest. 1994;7:148-156.
57. Brannan MD, Reidenberg P, Radwanski E, et al. Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations. Clin Pharmacol Ther. 1995;58: 269-278.
58. Stillwagon PK, Doyle WJ, Fireman P. Effect of an antihistamine/decongestant on nasal and eustachian tube function following intranasal pollen challenge. Ann Allergy. 1987;58:442-446.
59. Corren I, Aaronson D, Beaucher W, et al. A double-blind placebo controlled study of Claritin-D in patients with seasonal allergic rhinitis (SAR) and asthma (Abstract). Presented at the Collegium Internationale Allergologicum; September 6-11, 1996; Austria.
60. How is your doctor treating you? Consumer Reports. 1995;60:81.
61. Juniper EF, Guyatt GH. Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis. Clin Exp Allergy. 1991;21:77-83.
62. Juniper EF, Guyatt GH. Assessment of quality of life in adolescents with allergic rhinoconjunctivitis: Development and testing of a questionnaire for clinical trials. J Allergy Clin Immunol. 1994;98: 413-423.
63. Gilmore TM, Alexander BH, Mueller BA, Rivara FP. Occupational injuries and medication use. Am J Ind Med. 1996;30: 234-239.