Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and membrane transport, part I: Physicochemical and stability studies

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 3, 2002, Pages 315-323

  Chittchang, Montakarn ^a   Alur, Hemant H ^a   Mitra, Ashim K ^a   Johnston, Thomas P ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; POLYLYSINE; POLYPEPTIDE; PROTEIN DERIVATIVE;

ALPHA HELIX; ARTICLE; BETA SHEET; CHEMICAL MODEL; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; ENZYMATIC DEGRADATION; GASTROINTESTINAL TRACT; HYDROPHOBICITY; IONIC STRENGTH; LIPOPHILICITY; MACROMOLECULE; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MOLECULAR SIZE; PH; PHASE PARTITIONING; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; TEMPERATURE RELATED PHENOMENA;

CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; MOLECULAR CONFORMATION; POLYLYSINE; TEMPERATURE;

EID: 0036119627     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021778556     Document Type: Article

References (27)

1. Antineoplastic activity of poly(L-lysine) with some ascites tumor cells
2. Acetonitrile-induced conformational transitions in poly-L-lysine
3. Reversible configurational changes in poly-L-lysine hydrochloride induced by water
4. How structural features influence the biomembrane permeability of peptides
5. The α-helix to β-sheet transition in poly(L-lysine): Effects of anesthetics and high pressure
6. The optical rotatory dispersion of the beta structure of poly-L-lysine and poly-L-serine
7. Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly-L-lysine and administered to mice by intramuscular route
8. The helix-coil transition of poly-L-lysine in methanol-water solvent mixtures
9. The development of the prediction of protein structure
10. The transition of α-helix to β-structure of poly(L-lysine) induced by phosphatidic acid vesicles and its kinetics at alkaline pH
11. Delta-sleep-inducing peptide: Solution conformational studies of a membrane-permeable peptide
12. Computed circular dichroism spectra for the evaluation of protein conformation
13. Bioadhesive polymers in peptide drug delivery
14. Experimental free energy and enthalpy of formation of the α-helix
15. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
16. Infrared spectra and helical conformations
17. Improved ocular delivery of idoxuridine using the prodrug approach
18. Stabilization of the ribonuclease S-peptide α-helix by trifluoroethanol
19. Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
20. Potentiometric titration of poly-L-lysine: The coil-to-beta transition
21. Design of a well-absorbed renin inhibitor
22. Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells
23. Membrane transport of macromolecules: New carrier functions of proteins and poly(amino acids)
24. Effect of trifluoroethanol on protein secondary structure: An NMR and CD study using a synthetic actin peptide
25. A circular dichroism study of charged polypeptides interaction with salts
26. Three-dimensional structures of proteins
27. Transcellular and lipophilic complex-enhanced intestinal absorption of human growth hormone