Cross-sensitization to haptens: Formation of common haptenic metabolites, T cell recognition of cryptic peptides, and true T cell cross-reactivity

European Journal of Immunology

Volumn 32, Issue 5, 2002, Pages 1338-1348

  Wulferink, Marty ^a   Dierkes, Sabine ^a   Gleichmann, Ernst ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b Med Inst of Environmental Hygiene   (Germany)

Author keywords

Antigen presentation; CD4+ T lymphocyte; Epitope; Hypersensitivity; TCR

Indexed keywords

4 AMINOPHENOL; ANTIGEN; BASE; CHEMICAL COMPOUND; GLOBIN; HAPTEN; HEMOGLOBIN; PEPTIDE; PHENYLENEDIAMINE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CROSS ALLERGY; CROSS REACTION; FEMALE; HYBRIDOMA CELL CULTURE; IMMUNIZATION; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE;

AMINO ACID SEQUENCE; AMINOPHENOLS; ANIMALS; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CROSS REACTIONS; FEMALE; GLOBINS; HAPTENS; HYBRIDOMAS; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; OLIGOPEPTIDES; PHENYLENEDIAMINES; T-LYMPHOCYTES;

EID: 0036113272     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200205)32:5<1338::AID-IMMU1338>3.0.CO;2-4     Document Type: Article

References (25)

1. Cross-sensitizations between azo dyes and para-amino compound. A study of 236 azo-dye-sensitive subjects
2. Dissociation of allergenic and immunogenic functions in contact sensitivity to paraphenylenediamine
3. Investigation of the prohapten concept: Cross reactions between 1,4-substituted benzene derivatives in the guinea pig
4. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions
5. The local lymph node assay: A viable alternative to currently accepted skin sensitization tests
6. True cross-sensitization, false cross-sensitization and otherwise
7. Evaluation of cross-sensitization among dye-intermediate agents using a modified lymphocyte transformation test
8. Is benzoquinone the prohapten in cross-sensitivity among aminobenzene compounds?
9. Computerized analysis of concominant contact allergens
10. Alteration of model antigen A by Au(III) leads to T cell sensitization to cryptic peptides
11. Dominance and crypticity of T cell antigenic determinants
12. Selective protein covalent binding and target organ toxicity
13. p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates
14. Prostaglandin H. synthase catalyzed oxidation of hydroquinone to a sulfhydril-binding and DNA-damaging metabolite
15. Sensitivity to some rubber additives
16. Free radical formation and erythrocyte membrane alterations during MetHb formation induced by the BHA metabolite, tert-butylhydroquinone
17. The reaction of menadione with haemoglobin. Mechanism and effect of superoxide dismutase
18. MHC ligands and peptide motifs
19. Bandrowski's base
20. A very high level of crossreactivity is an essential feature of the T cell receptor
21. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
22. Use of global amino acid replacement to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103)
23. Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy
24. Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues
25. T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity