Comparative metabolism of N-tert-butyl-N-[1-(1-oxy-pyridin-4-yl)-ethyl]- and N-tert-butyl-N-(1-phenyl-ethyl)-nitroxide by the cytochrome P450 monooxygenase system

Chemical Research in Toxicology

Volumn 15, Issue 5, 2002, Pages 749-753

  Novakov, Christo P ^a   Stoyanovsky, Detcho A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; CYTOCHROME P450; DIMETHYL SULFOXIDE; HYDROXYL RADICAL; HYDROXYLAMINE; KETOCONAZOLE; N TERT BUTYL ALPHA (4 PYRIDYL 1 OXIDE) NITRONE; N TERT BUTYL ALPHA PHENYLNITRONE; N TERT BUTYL N (1 PHENYL ETHYL) NITROXIDE; N TERT BUTYL N [1 (OXY PYRIDIN 4 YL) ETHYL] NITROXIDE; NITROXIDE DERIVATIVE; PYRIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANAEROBIC METABOLISM; ARTICLE; BILE DUCT; CATALYSIS; ELECTRON SPIN RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; OXIDATIVE STRESS; RAT; REDUCTION; URINE; XENOBIOTIC METABOLISM;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; NADP; NITROGEN OXIDES; RATS;

ANIMALIA;

EID: 0036095665     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025510g     Document Type: Article

References (25)

1. Reevaluation of the Bond-Dissociation Energies (Delta-Hdbe) for H-OH, H-OOH, H-OO-, H-O., H-OO-, and H-OO
2. The centennial of the Fenton reaction
3. Role of free radicals and catalytic metal ions in human disease: An overview
4. Methods for the measurement of hydroxyl radicals in biomedical systems: Deoxyribose degradation and aromatic hydroxylation
5. Detection of oxygen-derived radicals in biological systems using electron spin resonance
6. Stabilities of hydroxyl radical spin adducts of PBN-type spin traps
7. Detection of radical adducts of 5,5-dimethyl-1-pyrroline n-oxide by the combined use of high-performance liquid chromatography with electrochemical detection and electron spin resonance
8. Detection and quantitation of hydroxyl radical using dimethyl sulfoxide as molecular probe
9. Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating systems
10. Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation
11. Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: An ESR spin-trapping investigation
12. ESR and HPLC-EC analysis of the interaction of hydroxyl radical with DMSO: Rapid reduction and quantification of POBN and PBN nitroxides
13. Spintrapping of methyl radical in the oxidative metabolism of 1,2-dimethylhydrazine
14. Spin trapping and its application in the study of lipid peroxidation and free radical production with liver microsomes
15. An esr and hple-ec assay for the detection of alkyl radicals
16. Metabolism of nitroxide spin labels in subcellular fraction of rat liver. I. Reduction by microsomes
17. ESR and HPLC-EC analysis of ethanol oxidation to 1-hydroxyethyl radical: Rapid reduction and quantification of POBN and PBN nitroxides
18. Inhibition of radical adduct reduction and reoxidation of the corresponding hydroxylamines in in vivo spin trapping of carbon tetrachloride-derived radicals
19. Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes
20. Aromatic hydroxylation in PBN spin trapping by hydroxyl radicals and cytochrome P-450
21. Biological spin trapping. II. Toxicity of nitrone spin traps: Dose-ranging in the rat
22. Colorimetric assay for methanesulfinic acid in biological samples
23. In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: Electron spin resonance spin trapping investigation
24. Dietary glycine and renal denervation prevents cyclosporin A-induced hydroxyl radical production in rat kidney
25. Oxidation of the ketoxime acetoxime to nitric oxide by oxygen radical-generating systems