Can ROI methodology/normalised tissue activities be used instead of absolute blood flow measurements in the brain?

European Journal of Nuclear Medicine

Volumn 29, Issue 7, 2002, Pages 948-956

  Costa, Durval C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRACER; DIAGNOSTIC AGENT; RADIOISOTOPE;

BLOOD FLOW; BLOOD FLOWMETRY; BRAIN BLOOD FLOW; BRAIN PERFUSION; BRAIN SIZE; CEREBROVASCULAR DISEASE; CIRCULATION; CLINICAL MEDICINE; DEMENTIA; DEPRESSION; EPILEPSY; FLOW RATE; HISTORY; HUMAN; MEDICAL LITERATURE; NONHUMAN; PHYSIOLOGY; QUANTITATIVE ANALYSIS; RADIOACTIVITY; REVIEW; TECHNIQUE; ARTICLE; BLOOD; BLOOD FLOW VELOCITY; BRAIN; BRAIN CIRCULATION; METABOLISM; METHODOLOGY; REFERENCE VALUE; SCINTISCANNING; VASCULARIZATION;

BLOOD FLOW VELOCITY; BRAIN; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; DEMENTIA; DEPRESSION; EPILEPSY; HUMAN; RADIOISOTOPES; RADIONUCLIDE IMAGING; REFERENCE VALUES; HUMANS;

EID: 0036095586     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-002-0837-y     Document Type: Review

References (35)

1. 1. Oxford English Dictionary, 2nd edn. (on CD ROM, Version 2.0), Oxford: Oxford University Press, 1999.
2. 2. Encarta World English Dictionary (World English Edition). Microsoft Corporation. 2001. Developed for Microsoft by Bloomsbury Publishing Plc. ( http://dictionary.msn.co.uk/find/)
3. 3. G Fallopius 1562 Observationes Anatomicae M.A. Ulmus Venice Fallopius G. Observationes Anatomicae. Venice: M.A. Ulmus, 1562.
4. 4. Vesalius A. De Humani Corporis Fabrica. Basle: J. Oporinus, 1543 (libri VII).
5. 5. W Harvey 1628 Exercitation Anatomica de Motu Cordis et Sanguinis in Animalibus G. Fitzeri Frankfurt Harvey W. Exercitation Anatomica de Motu Cordis et Sanguinis in Animalibus. Frankfurt: G. Fitzeri, 1628. (Facsimile and The Keynes English Translation of 1928, The Classics of Medicine Library, Birmingham, 1978)
6. 6. JJ Wepfer 1658 Observationes Anatomicae, ex Cadavericus Eorum, Quos Sustulit Apoplexia, cum Exercitatione de Eius Loco Affecto J.C. Suterus Achffhausen Wepfer JJ. Observationes Anatomicae, ex Cadavericus Eorum, Quos Sustulit Apoplexia, cum Exercitatione de Eius Loco Affecto. Achffhausen: J.C. Suterus, 1658.
7. 7. MW von Schulten 1885 Untersuchungen uber den Hirndruck, mit besonderer Rucksicht auf seine Einwirkung auf die Circulations-Verhaltnisse des Auges Arch Klin Chir 32 455 988 von Schulten MW. Untersuchungen uber den Hirndruck, mit besonderer Rucksicht auf seine Einwirkung auf die Circulations-Verhaltnisse des Auges. Arch Klin Chir 1885; 32:455–988.
8. 8. G Gartner J Wagner 1887 Ueber den Hirnkreislauf Wein Med Wochenschr 37 601 642 Gartner G, Wagner J. Ueber den Hirnkreislauf. Wein Med Wochenschr 1887; 37:601–642.
9. 9. PR Dumke CF Schmidt 1943 Quantitative measurements of cerebral blood flow in the macaque monkey Am J Physiol 138 421 431 Dumke PR, Schmidt CF. Quantitative measurements of cerebral blood flow in the macaque monkey. Am J Physiol 1943; 138:421–431.
10. 10. A Fick 1870 Ueber die Messung des Blutquantums in den Herzventrikeln Sitz Ber Physik-Med Ges Wurzburg 2 16 28 Fick A. Ueber die Messung des Blutquantums in den Herzventrikeln. Sitz Ber Physik-Med Ges Wurzburg 1870; 2:16–28.
11. 11. GN Stewart 1897 Researches on the circulation time and on the influences which affect it. IV. The output of the heart J Physiol 22 159 183 1512629 16992399 1:STN:280:DC%2BD2s%2FntFaqsA%3D%3D Stewart GN. Researches on the circulation time and on the influences which affect it. IV. The output of the heart. J Physiol 1897; 22:159–183.
12. 12. SS Kety 1951 The theory and applications of the exchange of inert gas at the lungs and tissues Pharmacol Rev 3 1 41 14833874 1:CAS:528:DyaG3MXjtVGgug%3D%3D Kety SS. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 1951; 3:1–41.
13. 13. NA Lassen O Munck 1955 The cerebral blood flow in man determined by the use of radioactive krypton Acta Physiol Scand 33 30 49 14349726 10.1111/j.1748-1716.1955.tb01191.x 1:CAS:528:DyaG2MXktlKqtw%3D%3D Lassen NA, Munck O. The cerebral blood flow in man determined by the use of radioactive krypton. Acta Physiol Scand 1955; 33:30–49.
14. 14. DH Ingvar NA Lassen 1961 Quantitative determination of regional cerebral blood flow in man Lancet 2 806 807 10.1016/S0140-6736(61)91092-3 Ingvar DH, Lassen NA. Quantitative determination of regional cerebral blood flow in man. Lancet 1961; 2:806–807.
15. 15. DH Ingvar NA Lassen 1962 Regional blood flow of the cerebral cortex determined by krypton85 Acta Physiol Scand 54 325 338 10.1111/j.1748-1716.1962.tb02356.x Ingvar DH, Lassen NA. Regional blood flow of the cerebral cortex determined by krypton85. Acta Physiol Scand 1962; 54:325–338.
16. 16. NA Lassen O Henriksen P Sejrsen 1983 Indicator methods for measurement of organ and tissue blood flow JT Sheperd FM Abboud SR Geiger Handbook of physiology III American Physiological Society Bethesda, Md. 21 63 Lassen NA, Henriksen O, Sejrsen P. Indicator methods for measurement of organ and tissue blood flow. In: Sheperd JT, Abboud FM, Geiger SR, eds. Handbook of physiology. Bethesda, Md.: American Physiological Society; 1983: vol III, sect 2, chap 2, pp 21–63.
17. 17. HF Kung M Blau 1980 Regional pH shift: a proposed mechanism for radiopharmaceutical uptake in brain and other tissues J Nucl Med 21 147 152 7356754 1:CAS:528:DyaL3cXhslKmtbg%3D Kung HF, Blau M. Regional pH shift: a proposed mechanism for radiopharmaceutical uptake in brain and other tissues. J Nucl Med 1980; 21:147–152.
18. 18. DC Costa 1989 A study of the first 99Tcm-labelled radiopharmaceutical for the investigation of cerebral blood flow in man University of London PhD thesis Costa DC. A study of the first 99Tcm-labelled radiopharmaceutical for the investigation of cerebral blood flow in man. PhD thesis: University of London, 1989.
19. 19. DC Costa 1989 A study of the first 99Tcm-labelled radiopharmaceutical for the investigation of cerebral blood flow in man University of London PhD thesis 52 68 Costa DC. A study of the first 99Tcm-labelled radiopharmaceutical for the investigation of cerebral blood flow in man. PhD thesis: University of London; 1989: chap 2.2, pp 52–68.
20. 20. JMP Oliveira PD Acton DC Costa 1992 Influence of reference structure in the quantification of brain perfusion maps with single photon emission tomography (SPET) Nucl Med Commun 18 320 321 10.1097/00006231-199704000-00108 Oliveira JMP, Acton PD, Costa DC. Influence of reference structure in the quantification of brain perfusion maps with single photon emission tomography (SPET). Nucl Med Commun 1992; 18:320–321.
21. 21. CA Trontzos B Ramon S Gacinovic DC Costa 2000 Quantitative analysis of brain perfusion studies: a simplified intra-and inter-observer comparative study Hellenic J Nucl Med 3 44 49 Trontzos CA, Ramon B, Gacinovic S, Costa DC. Quantitative analysis of brain perfusion studies: a simplified intra-and inter-observer comparative study. Hellenic J Nucl Med 2000; 3:44–49.
22. 22. I Podreka T Brücke S Asenbaum S Wenger S Aull C Vanr Meer de C Baumgartner 1993 Clinical decision making and brain SPECT DC Costa GF Morgan NA Lassen New trends in nuclear neurology and psychiatry John Libbey London 103 117 Podreka I, Brücke T, Asenbaum S, Wenger S, Aull S, Van der Meer C, Baumgartner C. Clinical decision making and brain SPECT. In: Costa DC, Morgan GF, Lassen NA, eds. New trends in nuclear neurology and psychiatry. London: John Libbey; 1993:103–117.
23. 23. K Van Laere C De Sadeleer A Dobbeleir A Bossuyt P De Deyn R Dierckx 1999 Quantification of 99Tcm-HMPAO brain SPET in two series of healthy volunteers using different tripleheaded SPET configurations: normal databases and methodological considerations Nucl Med Commun 20 1031 1040 10572913 10.1097/00006231-199911000-00008 1:STN:280:DC%2BD3c%2FjvFajug%3D%3D Van Laere K, De Sadeleer C, Dobbeleir A, Bossuyt A, De Deyn P, Dierckx R. Quantification of 99Tcm-HMPAO brain SPET in two series of healthy volunteers using different tripleheaded SPET configurations: normal databases and methodological considerations. Nucl Med Commun 1999; 20:1031–1040.
24. 24. KJ Friston AP Holmes KJ Worsley JB Poline CD Frith RSJ Frackowiak 1995 Statistical parametric maps in functional imaging: a general linear approach Human Brain Map 2 165 189 10.1002/hbm.460030303 Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Map 1995; 2:165–189.
25. 25. G Marchal C Serrati P Rioux MC Petit-Taboue F Viader V de la Sayette F Le Doze P Lochon JM Derlon JM Orgogozo 1993 PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome Lancet 341 925 927 8096267 10.1016/0140-6736(93)91214-7 1:STN:280:DyaK3s3htFajsQ%3D%3D Marchal G, Serrati C, Rioux P, Petit-Taboue MC, Viader F, de la Sayette V, Le Doze F, Lochon P, Derlon JM, Orgogozo JM. PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome. Lancet 1993; 341:925–927.
26. 26. HS Jorgensen B Sperling H Nakayama HO Raaschou TS Olsen 1994 Spontaneous reperfusion of cerebral infarcts in patients with acute stroke. Incidence, time course, and clinical outcome in the Copenhagen Stroke Study Arch Neurol 51 865 873 8080386 10.1001/archneur.1994.00540210037011 1:STN:280:DyaK2czmtFKhug%3D%3D Jorgensen HS, Sperling B, Nakayama H, Raaschou HO, Olsen TS. Spontaneous reperfusion of cerebral infarcts in patients with acute stroke. Incidence, time course, and clinical outcome in the Copenhagen Stroke Study. Arch Neurol 1994; 51:865–873.
27. 27. MD Devous Sr RA Thisted GF Morgan RF Leroy CC Rowe 1998 SPECT brain imaging in epilepsy: a meta-analysis J Nucl Med 39 285 293 9476937 Devous MD Sr, Thisted RA, Morgan GF, Leroy RF, Rowe CC. SPECT brain imaging in epilepsy: a meta-analysis. J Nucl Med 1998; 39:285–293.
28. 28. HS Mayberg PJ Lewis W Regenold HN Wagner Jr 1994 Paralimbic hypoperfusion in unipolar depression J Nucl Med 35 929 934 8195877 1:STN:280:DyaK2c3ltl2isA%3D%3D Mayberg HS, Lewis PJ, Regenold W, Wagner HN Jr. Paralimbic hypoperfusion in unipolar depression. J Nucl Med 1994; 35:929–934.
29. 29. BL Holman KA Johnson B Gerada PA Carvalho A Satlin 1992 The scintigraphic appearance of Alzheimer’s disease: a prospective study using technetium-99m-HMPAO SPECT J Nucl Med 33 181 185 1732438 1:STN:280:DyaK387itF2mug%3D%3D Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A. The scintigraphic appearance of Alzheimer’s disease: a prospective study using technetium-99m-HMPAO SPECT. J Nucl Med 1992; 33:181–185.
30. 30. W Jagust R Thisted MD Devous Sr R Ven Heertum H Mayberg K Jobst AD Smith N Borys 2001 SPECT perfusion imaging in the diagnosis of Alzheimer’s disease: a clinicopathologic study Neurology 56 950 956 11294935 10.1212/WNL.56.7.950 1:STN:280:DC%2BD3MzisV2lug%3D%3D Jagust W, Thisted R, Devous MD Sr, Ven Heertum R, Mayberg H, Jobst K, Smith AD, Borys N. SPECT perfusion imaging in the diagnosis of Alzheimer’s disease: a clinicopathologic study. Neurology 2001; 56:950–956.
31. 31. K Herholz H Schopphoff M Schmidt R Mielke W Eschner K Scheidhauer H Schicha W-D Heiss K Ebmeier 2002 Direct comparison of spatially normalized PET and SPECT scans in Alzheimer’s disease J Nucl Med 43 21 26 11801698 Herholz K, Schopphoff H, Schmidt M, Mielke R, Eschner W, Scheidhauer K, Schicha H, Heiss W-D, Ebmeier K. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer’s disease. J Nucl Med 2002; 43:21–26.
32. 32. AG Sorensen 2001 What is the meaning of quantitative CBF? AJNR Am J Neuroradiol 22 235 236 11156759 1:STN:280:DC%2BD3M7ntFCgtA%3D%3D Sorensen AG. What is the meaning of quantitative CBF? AJNR Am J Neuroradiol 2001; 22:235–236.
33. 33. AG Sorensen WA Copen L Ostergaard FS Buonanno RG Ganzalez G Rordorf BR Rosen LH Schwamm RM Weisskof WJ Koroshetz 1999 Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time Radiology 210 519 527 10207439 10.1148/radiology.210.2.r99fe06519 1:STN:280:DyaK1M3itlyntA%3D%3D Sorensen AG, Copen WA, Ostergaard L, Buonanno FS, Ganzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskof RM, Koroshetz WJ. Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time. Radiology 1999; 210:519–527.
34. 34. J Rother R Knab F Hamzei J Fiehler JR Reichenbach C Buchel C Weiller 2002 Negative dip in BOLD fMRI is caused by blood flow–oxygen consumption uncoupling in humans Neuroimage 15 98 102 11771977 10.1006/nimg.2001.0965 Rother J, Knab R, Hamzei F, Fiehler J, Reichenbach JR, Buchel C, Weiller C. Negative dip in BOLD fMRI is caused by blood flow–oxygen consumption uncoupling in humans. Neuroimage 2002; 15:98–102.
35. 35. PH Jarritt K Kouris 1993 Instrumentation for brain SPET: guidelines and quantification DC Costa GF Morgan NA Lassen New trends in nuclear neurology and psychiatry John Libbey London 39 62 Jarritt PH, Kouris K. Instrumentation for brain SPET: guidelines and quantification. In: Costa DC, Morgan GF, Lassen NA, eds. New trends in nuclear neurology and psychiatry. London: John Libbey; 1993:39–62.