Quantification of 99tcm-hmpao brain spet in two series of healthy volunteers using different triple-headed spet configurations normal databases and methodological considerations

Nuclear Medicine Communications

Volumn 20, Issue 11, 1999, Pages 1031-1040

  Van Laere, K ^a   De Sadeleer, C ^a   Dobbeleir, A ^b   Bossuyt, A ^c   De Deyn, P ^d   Dierckx, R ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b MIDDELHEIM HOSPITAL   (Belgium)

^c FREE UNIVERSITY OF BRUSSELS   (Belgium)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ARTICLE; BRAIN BLOOD FLOW; DATA ANALYSIS; DATA BASE; IMAGE ANALYSIS; METHODOLOGY; OBSERVER VARIATION; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ASSAY; REPRODUCIBILITY; RISK ASSESSMENT; ADULT; AGING; BRAIN; CLINICAL TRIAL; EVALUATION; FACTUAL DATABASE; FEMALE; HEMISPHERIC DOMINANCE; HUMAN; IMAGE PROCESSING; MALE; MIDDLE AGED; MULTICENTER STUDY; PHYSIOLOGY; SCINTISCANNING; SEXUAL DEVELOPMENT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STANDARD;

ADULT; AGING; BRAIN; DATABASES, FACTUAL; EVALUATION STUDIES; FEMALE; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; OBSERVER VARIATION; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SEX CHARACTERISTICS; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0032586060     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1080/00006231-199911000-00008     Document Type: Article

References (21)

1. Neirinckx RD, Canning LR, Piper IM et al. Technetium-99m d, l-HM-PAO: A new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med 1987; 28: 191-202.
2. American Academy of Neurology. Assessment of brain SPECT: Report of the therapeutics and technology assessment subcommittee. Neurology 1996; 46: 278-285.
3. Bartenstein P, Minoshima S, Hirsch C et al. Quantitative assessment of cerebral blood flow in patients with Alzheimer disease by SPECT. J Nucl Med 1997; 38: 1095-1101.
4. Dobbeleir A, Dierckx RA, Vandevivere J, De Deyn PP. Quantification in SPECT using non-invasive methods. In: De Deyn PP, Dierckx RA, Alavi A, Pickut BA, eds. SPECT in clinical neurology and psychiatry. London: John Libbey, 1997: 495-500.
5. Patterson J, Wyper DF. Basics of SPECT. In: Duncan R, ed. SPECT imaging of the brain. Dordrecht: Kluwer Academic, 1997: 1-42.
6. Catafau AM, Lomena FJ, Pavia J et al. Regional cerebral blood iflow patterns in normal young and aged volunteers: A 99mTc-HMPAO SPET study. Eur J Nucl Med 1996; 23: 1329-1337.
7. Dierckx RA, Dobbeleir A, Maes M, Pickut BA, Vervaet A, De Deyn PP. Parameters influencing SPECT regional brain uptake of Tc-99m HMPAO measured by calibrated point sources as external standard. Eur J Nucl Med 1994; 21: 514-520.
8. Dobbeleir A, Dierckx R. Quantification of technetium-99m hexamethylpropylene amine oxime brain uptake in routine clinical practice using calibrated point sources as an external standard: Phantom and human studies. Eur J Nucl Med 1993; 20: 684-689.
9. Deutsch G, Mountz JM, Katholi CR, Liu HG, Harrell LE. Regional stability of cerebral blood flow measured by repeated technetium-99m-HMPAO SPECT: Implications for the study of state-dependent change. J Nucl Med 1997; 38: 6-13.
10. Koyama M, Kawashima R, Ito H et al. SPECT imaging of normal subjects with technetium-99m-HMPAO and tech-netium-99m-ECD. J Nucl Med 1997; 38: 586-592.
11. Markus HS, Ring H, Kouris K, Costa DC. Alterations in regional cerebral blood flow, with increased temporal inter-hemispheric asymmetries, in the normal elderly: An HMPAO SPECT study. Nucl Med Commun 1993; 14: 628-633.
12. Matsuda H, Tsuji S, Shuke N, Sumiya H, Tonami N, Hisada K. A quantitative approach to technetium-99m hexame-thylpropylene amine oxime. Eur J Nucl Med 1992; 19: 195-200.
13. Mozley PD, Sadek AM, Alavi A et al. Effects of ageing on the cerebral distribution of technetium-99m hexamethylpropylene amine oxime in healthy humans. Eur J Nucl Med 1997; 24: 754-761.
14. Esposito G, Van Horn JD, Weinberger DR, Berman KF. Gender differences in cerebral blood flow as a function of cognitive state with SPET. J Nucl Med 1996; 37: 559-564.
15. Syed G, Eagger S, Toone B, Levy R, Barrett JJ. Quantification of regional cerebral blood flow (rCBF) using Tc-99m HM-PAO and SPECT: Choice of the reference region. Nucl Med Commun 1992; 13: 811-816.
16. Oliveira JMP, Acton PD, Costa DC. Influence of reference structure in the quantification of brain perfusion maps with single photon emission tomography (SPET). Nucl Med Commun 1997; 18: 320-321.
17. Elzer H, Henze M, Spierer FJ, Georgi P. Semiquantitative 99m-Tc-HMPAO SPECT in dementia of the Alzheimer type: Influence of the selection of reconstruction filter and reference region. Nuklearmedizin 1996; 35: 243-250.
18. Kojima A, Matsumoto M, Takahashi M, Hirota Y, Yoshida H. Effect of spatial resolution on SPECT quantification values. J Nucl Med 1989; 30: 508-514.
19. Frackowiack RSJ, Lenzi G-L, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using lsO and positron emission tomography: Theory, procedure and normal values. J Com-put Assist Tomogr 1980; 4: 727-736.
20. Leveille J, Demonceau G, Walovitch RC. Intrasubject comparison between technetium-99m-ECD and technetium-99-HMPAO in healthy human subjects. J Nucl Med 1992; 33: 480-484.
21. Oku N, Matsumoto M, Hashikawa K et al. Intra-individual differences between technetium-99m-HMPAO and technetium-99m-ECD in the normal medial temporal lobe. J Nucl Med 1997; 38: 1109-1111.