Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model

Skin Pharmacology and Applied Skin Physiology

Volumn 15, Issue 3, 2002, Pages 184-194

  Zareba, Grazyna ^a,b   Gelein, Robert ^a   Morrow, Paul E ^a   Utell, Mark J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Human skin nude mouse model; Octamethylcyclotetrasiloxane; Percutaneous absorption

Indexed keywords

OCTAMETHYLCYCLOTETRASILOXANE; SILICONE DERIVATIVE; UNCLASSIFIED DRUG; VOLATILE AGENT;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DERMIS; EPIDERMIS; EVALUATION; EVAPORATION; FECES; FEMALE; HUMAN; HUMAN TISSUE; KINETICS; LIPOPHILICITY; MODEL; MOUSE; NONHUMAN; NUDE MOUSE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RADIOACTIVITY; SKIN; SKIN ABSORPTION; SKIN TRANSPLANTATION; URINARY EXCRETION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ESTROGENS, NON-STEROIDAL; FEMALE; FETUS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; SILOXANES; SKIN ABSORPTION; SKIN TRANSPLANTATION; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0036089498     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063547     Document Type: Article

References (49)

1. Silicones
2. Toxicology of silicones
3. Distribution of silicones in water, sediment and fish in Japanese rivers
4. 14C-octamethylcyclotetrasiloxane in Fischer 344 rats
5. 4): Absence of immunological effects
6. 4)
7. 4 in immature rats using the uterotrophic assay
8. 4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28-day inhalation study
9. 4)
10. 4) in female Fischer 344 and Sprague-Dawley rats following nose-only inhalation exposure
11. 4) based on reproductive toxicity studies in Sprague-Dawley rats
12. One-generation inhalation reproductive toxicity study of hexamethyldisiloxane (HMDS) in rats
13. 4) in a 2-generation reproductive toxicity study in rats
14. 5) in a 2-generation inhalation reproductive toxicity study in rats
15. 4) vapor
16. Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in Fischer 344 rat urine
17. Aqueous solubility of permethylsiloxanes (silicones)
18. Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice
19. 5) in rats
20. Dermal absorption of siloxanes: Development of an in vitro model system and comparison to in vivo studies
21. 4) in human skin
22. 4
23. 4) in cosmetic formulation using the human skin/nude mouse model
24. Skin permeability in vivo comparison in rat, rabbit, pig and man
25. Animal models for percutaneous absorption
26. Evaluation of animal models for predicting skin penetration in man
27. Percutaneous penetration in the hairless dog, weanling pig and athymic nude mouse, evaluation of models for predicting skin penetration in man
28. Isolated perfused skin flap and skin grafting techniques
29. Human skin xenografts to athymic rodents as a system to study toxins delivered to or through skin
30. Biology of human skin transplanted to the nude mouse. 1. Response to agents which modify epidermal proliferation
31. Ponec Lipid composition and barrier function of human skin after grafting onto athymic nude mice
32. Application of hair analysis for biological monitoring of toxic substances in space
33. Biological monitoring of iodine, a water disinfectant for long-term space missions
34. Athymic nude mice and human skin grafting
35. In vivo percutaneous absorption studies of volatile solvents in hairless mice. I. Description of a skin-depot
36. Extraction of octamethylcyclotetrasiloxane and its metabolites from biological matrices
37. 4) in extracts of biological matrices by gas chromatography-mass spectrometry
38. Isolation of siloxane metabolites: An efficient extraction
39. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin
40. Comparisons of different animal skins with human skin in drug percutaneous penetration studies
41. Distribution and metabolism of topically applied ethanolamine
42. Development of human fetal skin transplanted to the nude mouse
43. Barrier properties of the newborn infant's skin
44. Development of the epidermis in the newborn
45. Percutaneous absorption of testosterone in the newborn rhesus monkey: Comparison to the adult
46. Epidermal lipids, barrier function, and desquamation
47. Percutaneous penetration of benzene in hairless mice: An estimate of dermal absorption during tire-building operations
48. In vivo percutaneous absorption studies of volatile organic solvents in hairless mice. II. Toluene, ethylbenzene, and aniline