Minimal contribution of cell-bound antibodies of to the immunoscintigraphy of inflamed joints with 99mTc-anti-CD4 monoclonal antibodies

NuklearMedizin

Volumn 41, Issue 3, 2002, Pages 129-134

  Kinne, R W ^a   Wolski, A ^a   Palombo Kinne, E ^a   Wolf, F ^a   Emmrich, F ^a   Becker, W ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Adjuvant arthritis; Anti CD4 mAb; Immunoscintigraphy; Macrophages; T cells

Indexed keywords

MONOCLONAL ANTIBODY; OKT 4 TC 99M; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG RELEASE; FEMALE; IMAGE ANALYSIS; IMMUNOSCINTIGRAPHY; IN VITRO STUDY; JOINT SCINTISCANNING; LEUKOCYTE ADHERENCE; NONHUMAN; ORGAN DISTRIBUTION; PERITONEUM MACROPHAGE; RADIOACTIVITY; RAT; T LYMPHOCYTE SUBPOPULATION; VALIDATION PROCESS; WHOLE BODY SCINTISCANNING;

EID: 0036088287     PISSN: 00295566     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1623888     Document Type: Article

References (16)

1. Imaging rheumatoid arthritis specifically with technetium-99m CD4-specific (T-helper lymphocytes) antibodies
2. The use of monoclonal antibodies and antibody fragments in the imaging of infectious lesions
3. Kinetics of 99mTc-labelled antibodies against CD4 (T-helper) lymphocytes in man
4. Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease
5. Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms
6. Rat adjuvant arthritis: Imaging with technetium-99m-anti-CD4 Fab' fragments
7. Comparison of 99mTc-labeled specific murine anti-CD4 monoclonal antibodies and nonspecific human immunoglobulin for imaging of inflamed joints in rheumatoid arthritis
8. Imaging of rheumatoid arthritis joints with 99mTechnetium-labeled specific anti-CD4- and non-specific immunoglobulins - Case report
9. Joint uptake and body distribution of a technetium-99m-labeled anti-rat-CD4 monoclonal antibody in rat adjuvant arthritis
10. Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes
11. The influence of anti-CD4 monoclonal antibody treatment on T-cell migration in adjuvant arthritis
12. Quantitative analysis of lymphocyte fluxes in vivo
13. Heterogeneity of lymphocyte homing physiology: Several mechanisms operate in the control of migration to lymphoid and non-lymphoid organs in vivo
14. The unique role of the spleen and its compartments in lymphocyte migration
15. Lymphocyte migration to the gut: Oversimplifications and controversial aspects
16. A novel approach to Tc-99-labeled monoclonal antibodies