Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 3 26-3, 2002, Pages

  Srinivasan, Suseela ^a   Strange, Jennifer ^b   Awonusonu, Feyisola ^a   Bruce, Margaret C ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Flow cytometry; Lipid interstitial fibroblasts; Lung development; PI 3 kinase; Ras raf MAP kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; LIPID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; FETUS; FETUS DEVELOPMENT; FETUS LUNG MATURATION; FLOW CYTOMETRY; GENE EXPRESSION; LUNG DEVELOPMENT; LUNG FIBROBLAST; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036087813     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00050.2001     Document Type: Article

References (30)

1. Developmental shift in the relative percentages of lung fibroblast subsets: Role of apoptosis postseptation
2. PDFG-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
3. Subpopulations of rat lung fibroblasts with different amounts off type I and type III collagen mRNAs
4. Proliferation of alveolar interstitial cells during postnatal lung growth
5. Transcriptional regulation of tropoelastin expression in rat lung fibroblasts: Changes with age and hyperoxia
6. Lung fibroblasts undergo apoptosis following alveolarization
7. Spatial and temporal differences in fibroblast behavior in fetal rat lung
8. Measurement of apoptotic cells in peripheral blood
9. Perinatal expression of genes that may participate in lipid metabolism by lipid-laden lung fibroblasts
10. Serine/threonine protein kinases and apoptosis
11. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
12. 15-Deoxy-delta-12,14-protstaglandin J2 is a ligand for the adipocyte determination factor PPAR-γ
13. Spectrofluorometric studies of the lipid probe, nile red
14. The lipid interstitial cell of the pulmonary alveolus
15. The postnatal growth of the rat lung. II. Autoradiography
16. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation
17. Ontogeny of apoptosis during lung development
18. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
19. Isolation and characterization of the lipid-containing interstitial cell from the developing rat lung
20. The pulmonary lipofibroblast (lipid interstitial cell) and its contributions to alveolar development
21. Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and MAP kinase-dependent manner
22. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
23. Apoptosis in the development of rat and human fetal lungs
24. Programmed cell death contributes to postnatal lung development
25. Insulin-like growth factor-1 is an essential regulator of the differentiation of 3T3-L1 adipocytes
26. Production and action of insulin-like growth factor I/somatomedin C in primary cultures of fetal lung fibroblasts
27. Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry
28. Impaired distal airway development in mice lacking elastin
29. Developmental regulation of the rat insulin-like growth factor I receptor gene
30. The IRS-signaling system: A network of docking proteins to IRS-1 in insulin signaling