Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 4 26-4, 2002, Pages

  Babal, Pavel ^a   Ruchko, Mykhaylo ^b   Ault Ziel, Kathryn ^a   Cronenberg, Lauren ^a   Olson, Jack W ^a   Gillespie, Mark N ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b Physics and Informatics   (Slovakia)

Author keywords

Polyamines; Pulmonary endothelial cells; Pulmonary hypertension

Indexed keywords

LACTACYSTIN; ORNITHINE DECARBOXYLASE; POLYAMINE; PROTEASOME; PROTEASOME INHIBITOR;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT;

EID: 0036086931     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00347.2001     Document Type: Article

References (37)

1. Evidence that hypoxic pulmonary vascular remodeling in rats is polyamine dependent
2. Multiple polyamine transport pathways in cultured pulmonary artery smooth muscle cells: Regulation by hypoxia
3. Cellular disposition of transported polyamines in hypoxic rat lung and pulmonary arteries
4. Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells
5. Glucocorticoid regulation of ornithine decarboxylase in the postnatal rat lung
6. + channels of their membrane
7. Activity-dependent modulation of glutamate receptors by polyamines
8. Role of ornithine decarboxylase in epidermal tumorigenesis
9. Antizyme, a mediator of ubiquitin-independent proteasomal degradation
10. Regulation of cellular polyamines by antizyme
11. Persistence, re-expression, and induction of pulmonary arterial fibronecitin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension
12. Alterations in extracellular matrix protein expression in neonatal pulmonary hypertension: Implications for vascular function
13. Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation
14. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species
15. Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells
16. Polyamine transport and ornithine decarboxylase activity in hypoxic pulmonary artery smooth muscle cells
17. Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1
18. Acute hypoxia induces elevation of ornithine decarboxylase activity in neonatal rat brain slices
19. Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain
20. Ornithine decarboxylase as an enzyme target for therapy
21. 2+-sensitive dehydrogenases respond
22. Connective tissue production by vascular smooth muscle in development and disease
23. Hypoxia and incorporation of 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall
24. Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression
25. The effect of chronic hypoxia on pulmonary arteries in young rats
26. Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells
27. Protective effect of spermine on DNA exposed to oxidative stress
28. EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs
29. Polyamine content in rat lung during development of hypoxia-induced pulmonary hypertension
30. Effect of spermine on mitochondrial glutathione release
31. Polyamine transport in mammalian cells. An update
32. Polyamine transport in mammalian cells
33. Mechanisms of lung polyamine accumulation in chronic hypoxic-pulmonary hypertension
34. Cellular and molecular mechanisms of pulmonary vascular remodeling
35. Temporal alterations in basement membrane components in the pulmonary vasculature of the chronically hypoxic rat: Impact of hypoxia and recovery
36. Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells
37. Oxygen sensing and signaling: Impact on the regulation of physiologically important genes