GABAA receptor activation at medullary sympathetic neurons contributes to postexercise hypotension

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 282, Issue 5 51-5, 2002, Pages

  Kajekar, Radhika ^a   Chen, Chao Yin ^a   Mutoh, Tatsushi ^b   Bonham, Ann C ^a,c  

^a Department of Internal Medicine ^*  (United States)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Central sympathetic network; Exracellular recording; Spontaneously hypertensive rats

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; EXERCISE; HYPOTENSION; MEDULLA OBLONGATA; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC NERVE; TREADMILL EXERCISE;

EID: 0036084424     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00725.2001     Document Type: Article

References (61)

1. The sympathetic system in hypertension
2. Anatomical substrates for baroreflex sympathoinhibition in the rat
3. Activity generated endorphins: A review of their role in sports science
4. Baroreceptor function and changes in strain sensitivity in normotensive and spontaneously hypertensive rats
5. Nonpharmacologic therapies that reduce blood pressure: A fresh perspective
6. GABAA and GABAB antagonists prevent the opioid inhibition of endogenous acetylcholine release evoked by glutamate from rat neostriatal slices
7. Post-exercise reduction of blood pressure in hypertensive men is not due to acute impairment of baroreflex function
8. Opioid receptor modulation of postexercise hypotension
9. Postexercise hypotension reduces cardiovascular responses to stress
10. Sinoaortic denervation prevents postexercise reductions in arterial pressure and cardiac sympathetic tonus
11. Arterial baroreflex resetting mediates postexercise reductions in arterial pressure and heart rate
12. Structural versus functional modulation of the arterial baroreflex
13. Aftereffects of exercise on regional and systemic hemodynamics in hypertension
14. Attenuation of postexertional hypotension by cardiac afferent blockade
15. Functional organization of central pathways regulating the cardiovascular system
16. Onset of exercise shifts operating point of arterial baroreflex to higher pressures
17. Naloxone as a GABA antagonist: Evidence from iontophoretic, receptor binding and convulsant studies
18. Comparison of three methods for the determination of baroreflex sensitivity in conscious rats
19. Labile hypertension and jogging: New diagnostic tool or spurious discovery
20. Postexercise hypotension and sympathoinhibition in borderline hypertensive men
21. The influence of thermoregulatory mechanisms on post-exercise hypotension in humans
22. Sympathetic-related activity of brain stem neurons in baroreceptor-denervated cats
23. Effects of gamma-aminobutyric acid on putative sympatho-excitatory neurons in the rat rostral ventrolateral medulla in vitro. Intracellular study
24. Role of the ventral medulla oblongata in blood pressure regulation
25. Rostral ventrolateral medulla and sympathorespiratory integration in rats
26. Role of excitatory amino acids in rat vagal and sympathetic baroreflexes
27. Sympathoexcitatory neurons of the rostroventrolateral medulla and the origin of the sympathetic vasomotor tone
28. Blood pressure and hemodynamic responses after exercise in older hypertensive men
29. Impaired sympathetic vascular regulation in humans after acute dynamic exercise
30. Acute postexercise blood pressure response of hypertensive and normotensive men
31. Effects of naloxone on hemodynamics and sympathetic activity after exercise
32. Influence of naloxone on muscle sympathetic nerve activity, systemic and calf hemodynamics and ambulatory blood pressure after exercise in mild essential hypertension
33. Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit
34. Opioid-and GABA(A)-receptors are co-expressed by neurons in rat brain
35. Effect of exercise on recovery blood pressure in normotensive and hypertensive subjects
36. A mathematical model to assess changes in the baroreceptor reflex
37. Sinoaortic regulatory system: Role in pathogenesis of essential and malignant hypertension
38. Postexercise hypotension is mediated by reductions in sympathetic nerve activity
39. Acute resetting of baroreceptor reflex in rabbits: A central component
40. Properties of presympathetic neurones in the rostral ventrolateral medulla in the rat: An intracellular study "in vivo"
41. Both central command and exercise pressor reflex reset carotid sinus reflex
42. Carotid sinus baroreceptor function in the spontaneously hypertensive rat
43. Reductions in blood pressure after acute exercise by hypertensive rats
44. Hypothalamic GABAergic influences on treadmill exercise responses in rats
45. Medial prefrontal depressor response: Involvement of the rostral and caudal ventrolateral medulla in the rat
46. Carotid baroreflex control of blood pressure and heart rate in men during dynamic exercise
47. GABA(A) receptors in the rostral ventrolateral medulla mediate the depressor response induced by stimulation of the greater splanchnic nerve afferent fibres in rats
48. Short-term effect of dynamic exercise on arterial blood pressure
49. Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats
50. Carotid baroreflex responsiveness during dynamic exercise in humans
51. Reflex control of the circulation during exercise: Chemoreflexes and mechanoreflexes
52. Modification of aortic baroreceptor resetting in the spontaneously hypertensive rat
53. Arterial baroreflex buffering of sympathetic activation during exercise-induced elevations in arterial pressure
54. Regulation of sympathetic tone and arterial pressure by rostral ventrolateral medulla after depletion of C 1 cells in rat
55. A review of the sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
56. Circulatory events following spontaneous muscle exercise in normotensive and hypertensive rats
57. Medullospinal sympathoexcitatory neurons in normotensive and spontaneously hypertensive rats
58. GABA-mediated baroreceptor inhibition of reticulospinal neurons
59. Effect of clonidine and gamma-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in the rat
60. The effects of acute and chronic morphine administration on GABA receptor binding
61. A GABAergic mechanism in the inhibition of cardiac vagal reflexes