Spreading and focusing of gluten epitopesin celiac disease

Gastroenterology

Volumn 122, Issue 7, 2002, Pages 2072-2075

  Martucci, Susi ^a   Corazza, Gino Roberto ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTEN; HLA ANTIGEN;

CELIAC DISEASE; CELL HETEROGENEITY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIET; EDITORIAL; IMMUNE RESPONSE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0036080083     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.34102     Document Type: Article

References (27)

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3. Wheat peptide challenge in coeliac disease
4. The intestinal T cell response in adult coeliac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
5. In vivo antigen challenge in coeliac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T cell epitope
6. Getting to grips with gluten
7. Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients
8. Glutenin is involved in the gluten-driven mucosal T cell response
9. The gluten response in children with recent onset celiac disease. A highly diverse response towards multiple gliadin and glutenin peptides
10. Tissue transglutaminase selectively modifies gliadin peptides that are recognised by gut-derived T cells in celiac disease
11. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis in the Sjl/j mouse
12. Epitope spreading
13. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease
14. Celiac disease and its link to type 1 diabetes mellitus
15. Immunologically ignorant auto reactive T cells, epitope spreading and repertoire limitation
16. Coeliac disease and secondary autoimmunity
17. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice
18. Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: A role for intramolecular epitope suppression
19. The frequency of high avidity T cells determines the hierarchy of determinant spreading
20. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease
21. Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed (with a edge on this bet)
22. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
23. Specific immunotherapy by genetically engineered APCs: The "guided missile" strategy
24. Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease
25. Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes
26. Clinical and pathological spectrum of coeliac disease-active, silent, latent, potential