Interleukin-4 and -13 promote basolateral secretion of H+ and cathepsin L by glomerular epithelial cells

American Journal of Physiology - Renal Physiology

Volumn 282, Issue 1 51-1, 2002, Pages

  Van Den Berg, José G ^a,c   Aten, Jan ^a   Annink, Carla ^a   Ravesloot, Jan H ^a   Weber, Ekkehard ^b   Weening, Jan J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Cathepsins; Minimal change nephrosis; Podocytes; Rab guanosinetriphosphatases; Vacuolar hydrogen adenosinetriphosphatase

Indexed keywords

BAFILOMYCIN A1; CATHEPSIN L; CYSTEINE PROTEINASE; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 13; INTERLEUKIN 4; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RAB PROTEIN;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EPITHELIUM CELL; GLOMERULUS FILTRATION; IMMUNOFLUORESCENCE; ION TRANSPORT; KIDNEY TUBULE EXCRETION; MINIMAL CHANGE GLOMERULONEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINURIA; RAT; T LYMPHOCYTE; TH2 CELL; TRANSCYTOSIS; WESTERN BLOTTING;

EID: 0036079870     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.0102.2001     Document Type: Article

References (36)

1. Atopy and steroid-responsive childhood nephrotic syndrome
2. Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis
3. Glomerular basement membrane degradation by endogenous cysteine proteinases in isolated rat glomeruli
4. Role of cathepsin B and L in anti-glomerular basement membrane nephritis in rats
5. Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane
6. Cathepsin B cathepsin H, and cathepsin L
7. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
8. The small GTPase rab 5 functions as a regulatory factor in the early endocytic pathway
9. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
10. The small GTPases Rab5a, Rab 5b and Rab5c are differentially phosphorylated in vitro
11. Multiple comparisons among means
12. Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone
13. Rab 7: An important regulator of late endocytic membrane traffic
14. Glomerular hypertrophy in minimal change disease predicts subsequent progression to focal glomerular sclerosis
15. +-ATPase
16. Gene regulation and extracellular functions of procathepsin L
17. Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro
18. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis
19. Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases
20. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome
21. Involvement of interleukin (IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome
22. Concentrations of lysosomal cysteine proteases are decreased in renal cell carcinoma compared with normal kidney
23. Cathepsin L. A new proteinase from rat-liver lysosomes
24. Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins
25. Metalloproteinase generation by human glomerular epithelial cells
26. The renal glomerulus of mice lacking s-laminin/laminin beta 2: Nephrosis despite molecular compensation by laminin beta 1
27. Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts
28. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death
29. Anti-Fx1A produces complement-dependent cytotoxicity of glomerular epithelial cells
30. Congenital nephrotic syndrome in mice lacking CD2-associated protein
31. Directed membrane transport is involved in process formation in cultured podocytes
32. The potential role of human kidney cortex cysteine proteinases in glomerular basement membrane degradation
33. Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells
34. Monoclonal antibodies against cathepsin L and procathepsin L of different species
35. Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: Evidence for increased IL-13 mRNA expression in relapse
36. Localization of cathepsin L in rat kidney revealed by immunoenzyme and immunogold techniques