Selective binding of trisamine-modified phosphorothioate antisense DNA to target mRNA improves antisense activity and reduces toxicity

Biochemical and Biophysical Research Communications

Volumn 293, Issue 5, 2002, Pages 1341-1347

  Matsukura, Makoto ^a   Okamoto, Tsuyosi ^b   Miike, Teruhisa ^a   Sawai, Hiroaki ^b   Shinozuka, Kazuo ^b  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Antisense DNA; Phosphorothioate oligomer; Selectivity; Trisamine

Indexed keywords

COMPLEMENTARY DNA; DEOXYURIDINE DERIVATIVE; MESSENGER RNA; OLIGOMER; PHOSPHOROTHIOIC ACID; RIBONUCLEASE H; TROMETAMOL;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; GENE ACTIVITY; GENE SEQUENCE; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MELTING POINT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; SEQUENCE ANALYSIS; TEMPERATURE; TREATMENT PLANNING; VIRUS INFECTION;

ANTI-HIV AGENTS; BASE SEQUENCE; CARBOXYLIC ACIDS; DNA; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV; HYDROLYSIS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN BINDING; RIBONUCLEASE H, CALF THYMUS; RNA, MESSENGER; TEMPERATURE; THERMODYNAMICS; TIME FACTORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036079347     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00383-2     Document Type: Article

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