Expression of tumor necrosis factor-α and interferon-γ mRNA in blood cells correlates with depression scores during an acute attack in patients with multiple sclerosis

Psychoneuroendocrinology

Volumn 27, Issue 6, 2002, Pages 671-681

  Kahl, K G ^a,c   Kruse, N ^a   Faller, H ^a   Weiss H ^b   Rieckmann, P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b ROBERT BOSCH HOSPITAL   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Depression; Multiple sclerosis; Th1 Th2 type cytokine

Indexed keywords

BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; BLOOD CELL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DISEASE COURSE; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RATING SCALE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SIGNAL DETECTION; TH1 CELL; TH2 CELL;

ADULT; DEPRESSION; FEMALE; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; MALE; MULTIPLE SCLEROSIS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036079118     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(01)00068-3     Document Type: Article

References (38)

1. Cloning and expression of a functional serotonin transporter from rat brain
2. Molecular physiology of norepinephrine and serotonin transporters
3. Cytokine gene expression in cells derived from CSF of multiple sclerosis patients
4. Sleep disturbance, depression and lesion site in patients with multiple sclerosis
5. Emotional impact of multiple sclerosis: Recent findings and suggestions for future research
6. Tumor necrosis factor-α production as a possible predictor of relapse in patients with multiple sclerosis
7. Depression, stress and immunological activation: The role of cytokines in depressive disorders
8. Immune-derived cytokines in the nervous system: Epigenetic instructive signals or neuropathogenic mediators?
9. Interleukin-6 (IL-6) plasma levels in depression and schizophrenia: Comparison between the acute state and after remission
10. Cloning of a serotonin transporter affected by antidepressants
11. Depression and multiple sclerosis
12. Quantification of cytokine mRNA expression by reverse transcriptase PCR in samples of previously frozen blood
13. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression
14. Increased serum interleukin-1-receptor antagonist concentrations in major depression
15. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression
16. Interferons as mediators of psychiatric morbidity: An investigation in a trial of recombinant alpha-interferon in hepatitis-B carriers
17. Depression in multiple sclerosis as a function of length and severity of illness, age remission and perceived social support
18. Depression in multiple sclerosis
19. Affective disorders in multiple sclerosis: Review and recommendations for clinical research
20. Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6
21. Data on cytokine mRNA expression in CSF and peripheral blood mononuclear cells from MS patients as detected by PCR
22. Effects of interferon-α, interferon-γ and cAMP on the transcriptional regulation of the serotonin transporter
23. Investigations of the cellular immunity during depression and the free interval; Evidence for an immune activation in affective psychosis
24. Increased soluble interleukin-2 receptor concentrations in suicide attempters
25. In vitro TNF-alpha, IL-1 and IFN-gamma production as markers of relapses in multiple sclerosis
26. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
27. Structural brain correlates of emotional disorder in multiple sclerosis
28. Psychiatric complications of long-term interferon alpha therapy
29. Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity
30. Depression and multiple sclerosis
31. Increased CD56+ natural killer cells and related cytokines in major depression
32. Indicators of immune activation in major depression
33. The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis
34. Tritiated imipramin binding sites are decreased in the frontal cortex of suicides
35. An investigation into some psychiatric aspects of multiple sclerosis
36. Nonsuppression of cortisol in depression and immune function
37. Cytokine mRNA profile of myelin-basic protein reactive T-cell clones in patients with multiple sclerosis