Protein phosphatase type 1-dependent dephosphorylation of the retinoblastoma tumor suppressor protein in ultraviolet-irradiated human skin and keratinocytes

Journal of Investigative Dermatology

Volumn 115, Issue 1, 2000, Pages 88-94

  Edwards, Malcolm J ^a   Thomas, Robert C ^b  

^a CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Human skin; Keratinocytes; Retinoblastoma tumor suppressor protein; Ultraviolet radiation

Indexed keywords

GENE PRODUCT; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; RETINOBLASTOMA PROTEIN;

ARTICLE; BASAL CELL; CELL CYCLE PHASE; CELL NUCLEUS; CONTROLLED STUDY; DEPHOSPHORYLATION; EPIDERMIS CELL; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; KERATINOCYTE; MITOSIS SPINDLE; NUCLEOLUS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; ULTRAVIOLET IRRADIATION; WESTERN BLOTTING;

EID: 0033925887     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00026.x     Document Type: Article

References (53)

1. Alberts AS, Thorburn AM, Shenolikar S, Mumby MC, Feramisco JR: Regulation of cell cycle progression and the nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci USA 90:388-392, 1993
2. 2 phases during hypoxic stress. Exp Cell Res 227:106-115, 1996
3. An B, Dou QP: Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate. Cancer Res 56:428-442, 1996
4. Barker D, Dixon K, Medrano EE, et al: Comparison of the responses of human melanocytes with different melanin contents to UVB irradiation. Cancer Res 55:4041-4046, 1995
5. Chellappan SP, Hiebert S, Mudryl M, Horowitz JM, Nevins JR: The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053-1061, 1991
6. Chen P-L, Scully P, Shew J-Y, Mudryj M, Horowitz JM, Nevins JR: Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193-1198, 1989
7. Coohill T, Peak M, Peak J: The effects of ultraviolet wavelengths of radiation present in sunlight on human cells in vitro. Photochem Photobiol 46:1043-1050, 1987
8. De Caprio JA, Ludlow JW, Lynch D: The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085-1095, 1989
9. Deirdre AN, Krucher NA, Ludlow JW: High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma protein. J Biol Chem 272:4528-4535, 1997
10. Devary Y, Gottlieb RA, Seal T, Karin M: The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase. Cell 71:1081-1091, 1992
11. Devary Y, Rosette C, DiDonato JA, Karin M: NF-κB activation by ultraviolet light is not independent on a nuclear signal. Science 261:1442-1445, 1993
12. 1 arrest and apoptosis. Proc Natl Acad Sci USA 92:9019-0923, 1995
13. Dowby SF, Hinds PW, Louie K: Physical interactions of the retinoblastoma protein with human D cyclins. Cell 73:499-511, 1993
14. Dulic V, Kaufmann WK, Wilson SJ, et al: p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation induced G1 arrest. Cell 76:1013-1023, 1994
15. Durfee T, Becherer K, Chen P-L: The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev 7:555-569, 1993
16. Duronio RJ, Brook A, Dyson N, O'Farrell PH: E2F induced S phase requires cyclin E. Genes Dev 10:2505-2513, 1996
17. Edwards MJ, Dykes PJ, O'Donovan MR, Merrett VR, Morgan HE, Marks R: Induction of heat shock proteins as a measure of chemical cytotoxicity. Toxicology In Vitro 4:270-276, 1990
18. El-Deiry WS, Tokino T, Velculescu VE: WAF1, a potential mediator of p53 tumour suppression. Cell 75:817-825, 1993
19. Engelberg D, Klein C, Martinetto H, Struhl K, Karin M: The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell 77:381-390, 1994
20. Ewen ME, Sluss HK, Sheer CJ, Matsushime H, Kato J, Livingstone DM: Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497, 1993
21. Fernandez A, Brautigan DL, Lamb NJC: Protein phosphatase type 1 in mammalian cell mitosis: Chromosomal localization and involvement in mitotic exit. J Cell Biol 116:1421-1430, 1992
22. 1 phase of the cell cycle. Cell 67:293-302, 1991
23. Haapajarvi T, Kivinen L, Pitkanen K, Laiho M: Cell cycle dependent effects of UV-radiation on p53 expression and retinoblastoma protein phosphorylation. Oncogene 11:151-159, 1995
24. Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T'Ang A, Fung YK, Israel MA: Inhibition of apoptosis by the retinoblastoma product. EMBO J 14:461-472, 1995
25. 1 cyclin dependent kinases. Cell 75:805-816, 1993
26. Hartwell L: Defects in cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71:543-546, 1992
27. Hartwell LH, Kastan MB: Cell cycle control and cancer. Science 266:1821-1828, 1994
28. Herwig S, Strauss M: The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem 246:581-601, 1997
29. Higjiki H, Suganuma M: Tumour promotion by inhibition of protein phosphatase 1 and 2A the okadaic acid class of compounds. Adv Cancer Res 61:143-194, 1993
30. Hipskind RA, Baccarino M, Nordheim A: Transient activation of RAF-1, MEK and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate early gene promoter activity in vivo. Mol Cell Biol 14:6219-6231, 1994
31. Hu Q, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E: Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol Cell Biol 11:5792-5799, 1991
32. Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ: Direct binding of cyclin D to the retinoblastoma gene product (pRB) and pRB phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7:331-342, 1993
33. Krtolica A, Krucher NA, Ludlow JW: Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities. Oncogene 17:2295-2304, 1998
34. Krucher NDA, Ludlow JW: High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma protein. J Biol Chem 272:4528-4535, 1997
35. Laemmli UK: Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
36. Lees JA, Saito M, Vidal M: The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol 13:7813-7825, 1993
37. WAF1/CIP1 protein in keratinocytes without p53. J Invest Dermatol 113:283-284, 1999
38. Ludlow JW, Glendening CL, Livingstone DM, DeCaprio JA: Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol 13:367-372, 1993
39. Waf-1/SDI-1/Cip-1 protein. Cancer Res 55:4047-4052, 1995
40. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D: Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54:3391-3395, 1994
41. Mihara K, Cao XR, Yen A: Cell cycle-dependent regulation of phosphorylation of human retinoblastoma gene product. Science 246:1300-1303, 1989
42. Nelson DA, Ludlow JW: Characterisation of the mitotic phase pRB-directed protein phosphatase activity. Oncogene 14:2407-2415, 1997
43. Pallen CJ, Tan YH, Guy G: Protein phosphatases in cell signalling. Curr Opin Cell Biol 4:1000-1007, 1992
44. Pedley J, Ablett EM, Pettit A, Meyer J, Dunn IS, Sturn RA, Parsons PG: Inhibition of retinoblastoma protein translation by UVB in human melanocytic cells and reduced cell cycle arrest following repeated irradiation. Oncogene 13:1335-1342, 1996
45. 1 and S phase checkpoints. Oncogene 1:1387-1396, 1996
46. Puntoni F, Villa-Moruzzi E: Association of protein phosphatase-1delta with the retinoblastoma protein and reversible phosphatase activation in mitotic HeLa cells and in cells released from mitosis. Biochem Biophys Res Comm 235:704-708, 1997
47. Radler-Pohl A, Sachsenmaier C, Gebel S: UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-kinase. EMBO J 12:1005-1012, 1993
48. Roddey PK, Garmyn M, Park H-Y, Bhawan J, Gilchrist BA: Ultraviolet irradiation induces c-fos but not c-Ha-Ras protoncogene expression in human epidermis. J Invest Dermatol 102:296-299, 1989
49. Shenolikar S: Protein serine/threonine phosphatases - new avenues for cell regulation. Annu Rev Cell Biol 10:55-86, 1994
50. Strauss M, Lukas J, Bartek J: Unrestricted cell cycling and cancer. Nat Med 1:1245-1246, 1995
51. Thomas RC, Edwards MJ, Marks R: Translocation of the retinoblastoma gene product during mitosis. Exp Cell Res 223:227-232, 1996
52. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354, 1979
53. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81:323-330, 1995