Historical development of the concept of the gene

Journal of Medicine and Philosophy

Volumn 27, Issue 3, 2002, Pages 257-286

  Portin, Petter ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Cistron; Gene function; Genetic complementation; Genetic recombination; Genome; Genomics; Mutation

Indexed keywords

IMMUNOGLOBULIN; MESSENGER RNA; NUCLEOTIDE; POLYPEPTIDE; POLYPROTEIN;

ALTERNATIVE RNA SPLICING; CISTRON; DNA DETERMINATION; ENHANCER REGION; GENE FUNCTION; GENE MUTATION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC COMPLEMENTATION; GENETIC ORGANIZATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETICS; GENOME; GENOTYPE; PHENOTYPE; POLYADENYLATION; PROMOTER REGION; PSEUDOGENE; REVIEW; RNA SYNTHESIS;

GENETICS; GENETICS, POPULATION; HISTORY, 20TH CENTURY; HUMANS; MOLECULAR BIOLOGY; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 0036068998     PISSN: 03605310     EISSN: None     Source Type: Journal    
DOI: 10.1076/jmep.27.3.257.2980     Document Type: Review

References (192)

1. The genome sequence of Drosophila melanogaster
2. Population dynamics of transposable elements
3. The transformation in vitro of R pneumococci into S forms of different specific types by the use of filtered pneumococcus extracts
4. Generation of protein isoform diversity by alternative splicing: Mechanistic and biological implications
5. The Drosophila genome project: A progress report
6. Drosophila comes of age - The sequence
7. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcal type III
8. Expression of a globin gene is enhanced by remote SV40 DNA sequences
9. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
10. Alternative splicing of a Drosophila trompomyosin gene generates muscle trompomyosin isoforms with different carboxyterminal ends
11. Genetic control of biochemical reactions in Neurospora
12. Sequence of the human insulin gene
13. The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages
14. Fine structure of a genetic region in bacteriophage
15. The elementary units of heredity
16. On the topology of the genetic fine structure
17. On the topography of the genetic fine structure
18. Spliced segments at the 5′ termini of adenovirus-2 late mRNA: A role for heterogenous nuclear RNA in mammalian cells
19. Splicing early mRNAs of SV40
20. Distribution of transposable elements in Drosophila species
21. The Q locus of Neurospora
22. Über mehrpolige Mitosen als Mittel zur Analyse des Zellkerns
23. Über die Konstitution der chromatischen Kernsubstanz
24. Ovalbumin gene is split in chicken DNA
25. An unstable intermediate carrying information from genes to ribosomes for protein synthesis
26. Non-disjunction as proof of the chromosome theory of heredity
27. Salivary chromosome maps with a key to the banding of the chromosomes of Drosophila melanogaster
28. Correspondence between linkage maps and salivary chromosome structure as illustrated in the tip of chromosome 2R of Drosophila melanogaster
29. A revised map of the salivary gland X-chromosome of Drosophila melanogaster
30. Nucleotide sequence repetition in DNA
31. Repeated sequences in DNA
32. Repeated nucleotide sequences
33. Adenovirus-2 messenger - An example of baroque molecular architecture
34. Purification and some characteristics of 5S DNA from Xenopus laevis
35. On conceptual change in biology: The case of the gene
36. Sequence heterogeneity at the 5′ termini of late SV40 19S and 16S mRNAs
37. At least two genes reside within a large intron of the dunce gene of Drosophila
38. Comparison of the complete protein sets of worm and yeast: Orthology and divergence
39. The 5′ terminal leader sequence of the late 16s mRNA from cells infected with SV40
40. Heterogeneity and 5′ terminal structures of the late RNAs of SV40
41. + bacteriophage
42. Construction of biologically functional bacterial plasmids in vitro
43. Transposable genetic elements
44. Overlapping of the CP2-VP3 gene and the VP1 gene in the SV40 genome
45. G. Mendel's Regel über das Verhalten der Nachkommenschaft der Rassenbastarde
46. Organization of the rat gamma-fibrinogen gene: Alternative mRNA splice patterns produce the A and gamma B (gamma') chains of fibrinogen
47. On the separation of the tryptophan synthetase of Escherichia coli into two protein components
48. Organization and expression of early genes of SV40
49. Specific cleavage of simial vitus 40 DNA by restriction endonuclease of Hemophilus influenzae
50. The molecular conservation of ribonucleic acid during bacterial growth
51. In vitro transformation of pneumococcal types. I. A technique for inducing transformation of pneumococcal types in vitro
52. Das Spaltungsgesetz der Bastarde
53. Properties of genes
54. Everyone's genome
55. Genetical and cytological proof of translocations involving the third and fourth chromosome in Drosophila melanogaster
56. Polyprotein gene expression: Generation of diversity of neuroendocrine peptides
57. Duplicating mechanism for peptide chain and nucleic acid synthesis
58. The DNA sequence of human chromosome 22
59. Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways
60. Immunoglobulin heavy chain gene organization in mice: Analysis of a myeloma genomic clone containing variable and α constant regions
61. Overlapping transcription units in Drosophila: Sequence and structure of the Cs gene
62. Transposable genetic elements in maize
63. Complete nucleotide sequence of SV40 DNA
64. Multiple 5′ terminal cap structures in late polyoma virus RNA
65. Possible relation between deoxyribonucleic acid and protein structures
66. Studies on the mechanism of reversion in biochemical mutants of Neurospora crassa
67. A tissue-specific transcription enhancer elements is located in the major intron of a rearranged immunoglobulin heavy chain gene
68. Life with 6000 genes
69. Crossing over between alleles of the lozenge locus in Drosophila melanogaster
70. Significance of pneumococcal types
71. The life of Gregor Johan Mendel - Tragic or not?
72. The DNA sequence of human chromosome 21
73. Gene within a gene: Nested Drosophila genes encode unrelated proteins on opposite DNA strands
74. Nucleic acid economy in bacteria infected with bacteriophage T2. II. Phage precursor nucleic acid
75. Independent functions of viral protein and nucleic acid in growth of bacteriophage
76. Nucleic acid economy in bacteria infected with bacteriophage T2
77. Polyoma infected cells contain at least three spliced late RNAs
78. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions
79. Initial sequencing and analysis of the human genome
80. Biochemical method for inserting new genetic information into DNA of simian virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli
81. Molecular and biological characterization of messenger RNA
82. A pseudogene structure in 5S DNA of Xenopus laevis
83. The rabbit β-globin gene contains a large insert in the coding sequence
84. The natural selection theory of antibody formation
85. Expression of three mRNA species from a single rat aldolase A gene, differing in their 5′ non-coding regions
86. Histone genes and histone messengers
87. A restriction enzyme from Hemophilus influenzaea. II. Base sequence of the recognition site
88. Gene: Current usages
89. Two adenovirus mRNAs have a common 5′ terminal leader sequence encoded of least 10 kb upstream from their main coding regions
90. The sequence of the chromosomal mouse β-globulin major gene: Homologies in capping, splicing and poly (A) sites
91. Mapping the spliced and unspliced late lytic SV40 mRNAs
92. Complex transcriptional units: Diversity in gene expression by alternative RNA processing
93. A transcribed gene in an intron of the human factor VIII gene
94. Alternatives for splicing: Recognizing the ends of introns
95. Another case of unequal crossing over in Drosophila melanogaster
96. Genotype and phenotype
97. Host specificity of DNA produced by Escherichia coli. X. In vitro restriction of phage fd replicative form
98. Enzymatic end-to-end joining of DNA molecules
99. The structure and evolution of the two nonallelic rat preproinsulin genes
100. Many protein products from a few loci: Assigment of human salivary proline-rich proteins to specific loci
101. What exactly are genomes, genotypes and phenotypes? And what about phenomes?
102. Characterization of 3 optional promoters in the 5′ region of the human aldolase A gene
103. The metabolism of ribonucleic acid in normal and bacteriophage infected E. coli
104. A new method for sequencing DNA
105. Cytogenetic studies of maize and Neurospora
106. Mutable loci in maize
107. Two regions of the adenoviru 2 genome specify families of late polysomal RNAs containing common sequences
108. A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T iso-forms from a single gene
109. Versuche über Pflanzenhybriden
110. Cleavage of DNA by RI restriction endonuclease generates cohesive ends
111. DNA restriction enzyme from E. coli
112. Visualization of nucleolar genes
113. Extrachromosomal nucleolar genes in amphibian oocytes
114. Portrait of a gene
115. Expression of IgD may use both DNA rearrangement and RNA splicing mechanism
116. The SV40 72 bp repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants
117. Artificial transmutation of the gene
118. The problem of genic modification
119. The cytological expression of changes in gene alignment produced by X-rays in Drosophila
120. + nuclear sequences are conserved and poly (A) additions precedes splicing
121. Sitzungsberichte Jahresversammlung am 8. Jänner 1902
122. Sitzungsberichte Jahresversammlung am 11. Jänner 1905
123. A reversion to wild type associated with crossing over in Drosophila melanogaster
124. A new method for the study of chromosome aberrations and the plotting of chromosome maps in Drosophila melanogaster
125. Large and small tumor antigens from SV40 have identical amino termini mapping at 0.65 map units
126. Identification of an alternative open reading frame ("Hidden Gene"?) stringently required for infectivity of poliovirus cDNA clones
127. The genetic formulation of gene structure and action
128. The linear arrangement of a series of alleles of Aspergillus nidulans
129. On the expression of a structural gene
130. Search for linkage between genes determining a vitamin requirement
131. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA fragments
132. Nucleotide sequence of bacteriophage ΦX 174 DNA
133. DNA sequencing with chain termination inhibitors
134. Co-linearity of the gene with the polypeptide chain
135. Neuropeptides: Mediators of behavior in aplysia
136. Alternative promoters in developmental gene expression
137. In vivo developmental modifications of the expression of genes encoding muscle-specific enzymes in rat
138. Enhancers and trans-acting factors
139. Enhancers and eukaryotic gene transcription
140. Detection of two restriction endonuclease activities in Hemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis
141. Gene K, a new overlapping gene in bacteriophage G4
142. Different tissue-specific expression of the alpha-amylase gene Amy-1 in mouse and rat
143. A restriction enzyme from Hemophilus influenzae. I. Purification and general properties
144. Detection of specific sequences among DNA fragments separated by gel electrophoresis
145. Overlapping transcription units in the dopa decarboxylase region of Drosophila
146. The ornithine cycle in Neurospora and its genetic control
147. The linear arrangement of the six sex-linked factors in Drosophila, as shown by their mode of association
148. The chromosomes in heredity
149. Analysis of the genome sequence of the flowering plant Arabidopsis thalian
150. Genome sequence of the nematode C. elegans: A platform for investigating biology
151. Intervening sequence of DNA identified in the structural portion of mouse β-globin gene
152. Organization of immunoglobulin genes
153. Ueber Künstliche Kreuzung bei Pisum sativum
154. Expressing the human genome
155. The sequence of the human genome
156. The function of RNA in T2-infected bacteria
157. Phosphorus incorporation in Escherichia coli ribonucleic acid after infection with bacteriophage T2
158. Intracellular distribution of labeled ribonucleic acid after infection of Escherichia coli with bacteriophage T7
159. Metabolism of RNA phophorus in Escherichia coli infected with bacteriophage T7
160. Nucleotide sequence repetition: A rapidly reassociating fraction of mouse DNA
161. Genes made molecular
162. Involvement of RNA in the synthesis of proteins
163. A structure for deoxyribonucleic acid
164. Genes coding for polysomal 9S RNA of sea urchins: Conservation and divergence
165. Sometimes an editor makes sense
166. Displacement loops in adenovirus DNA-RNA hybrids
167. A mouse locus at which transcription from both DNA strand produces mRNAs complementary at their 3′ ends
168. Control of messenger RNA concentration by different cytoplasmic half-life. Adenovirus messenger RNAs from transcription units 1A and 1B
169. Weitere experimentelle Untersuchungen über Artveränderung, speziell über das Wesen quantitativer, Unterschiede der Daphniden
170. Fine structural analysis of the chicken pro-α2 collagen gene
171. Structure of the pro-α2 (I) collagen gene
172. The neurofibromatosis type 1 gene encodes a protein related to GAP
173. The collagen gene: Evidence for its evolutionary assembly by amplification of a DNA segment containing an exon of 54 bp
174. The effects of deletions, point mutations on the two components of the tryptophan synthetase of Escherichia coli
175. On the colinearity of gene structure and protein structure
176. The complete amino acid sequence of the tryptophan synthetase A protein (α subunit) and its colinear relationship with the genetic map of the A gene
177. A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs
178. Adenovirus type 2 late mRNAs: Structural evidence for 3′ conterminal species