Effect of locally administered anti-CD154 (CD40 ligand) monoclonal antibody on survival of allogeneic corneal transplants

Cornea

Volumn 21, Issue 6, 2002, Pages 592-597

  Qian, Ying ^a   Dana, M Reza ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

CD40 CD154 costimulation; Corneal neovascularization; Corneal transplantation; Graft survival; Ocular anti CD154 therapy

Indexed keywords

CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G ANTIBODY;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; CORNEA TRANSPLANTATION; DRUG EFFICACY; GRAFT REJECTION; GRAFT SURVIVAL; HIGH RISK POPULATION; HISTOPATHOLOGY; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SLIT LAMP; SURVIVAL RATE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CD40 LIGAND; CORNEA; CORNEAL NEOVASCULARIZATION; CORNEAL TRANSPLANTATION; GRAFT REJECTION; GRAFT SURVIVAL; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TRANSPLANTATION, HOMOLOGOUS;

EID: 0036068382     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003226-200208000-00012     Document Type: Article

References (30)

1. Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody
2. Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice
3. CD4+ T cells are critical for corneal, but not skin, allograft rejection
4. Costimulatory regulation of T cell function
5. The role of CD40 ligand in costimulation and T-cell activation
6. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
7. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
8. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
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10. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
11. Anti-CD154 monoclonal antibody and thromboembolism
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13. Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice
14. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39
15. Induction of anterior chamber-associated immune deviation by corneal allografts placed in the anterior chamber
16. The collaborative corneal transplantation studies (CCTS): Effectiveness of histocompatibility matching in high-risk corneal transplantation
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18. CD40 is functionally expressed on human thymic epithelial cells
19. A central role of CD40 ligand in the regulation of CD4+ T-cell responses
20. Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidney
21. CD40 expression on normal and cultured human corneal cells
22. Expression of CD40 and CD40 ligand in the human conjunctival epithelium
23. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes
24. Effect of topical interleukin-1 receptor antagonist on corneal allograft survival in presensitized hosts
25. CD4+ T cells are critical for corneal, but not skin, allograft rejection
26. CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway
27. CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection
28. Loss and restoration of immune privilege in eyes with corneal neovascularization
29. T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: Implications for tubule formation
30. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes