Erythrocyte calpain is dispensable for malaria parasite invasion and growth

Molecular and Biochemical Parasitology

Volumn 122, Issue 2, 2002, Pages 227-229

  Hanspal, Manjit ^a   Goel, Vikas K ^a   Oh, Steven S ^a   Chishti, Athar H ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cysteine proteases; Malaria; mu calpain; Plasmodium falciparum

Indexed keywords

CALCIUM; CALPAIN; CYSTEINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE COUNT; GROWTH RATE; HEMATOCRIT; HETEROZYGOTE; HOMOZYGOTE; HOST PARASITE INTERACTION; INCUBATION TIME; INFECTION RATE; LEUKOCYTE; MALARIA; MEROZOITE; MICROBIAL GROWTH; MOUSE; MOUSE MUTANT; NONHUMAN; NULL ALLELE; PARASITE DEVELOPMENT; PARASITE ISOLATION; PARASITEMIA; PATHOGENICITY; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; PROTEIN FUNCTION; STAINING; TROPHOZOITE;

ANIMALS; CALPAIN; ERYTHROCYTES; HUMANS; MALARIA; MALARIA, FALCIPARUM; MICE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII;

ANIMALIA; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII;

EID: 0036068196     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00104-4     Document Type: Article

References (16)

1. Proteases of malaria parasites: New targets for chemotherapy
2. A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin
3. Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1
4. The proteases and pathogenicity of parasitic protozoa
5. Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis
6. Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium falciparum
7. 2+ depletion on the asexual cell cycle of Plasmodium falciparum
8. Calpain: Novel family members, activation, and physiologic function
9. Regulation of the calpain-calpastatin system by membranes
10. Disruption of the mouse mu-calpain gene reveals an essential role in platelet function
11. Invasion of mouse erythrocytes by the human malaria parasite, Plasmodium falciparum
12. Binding of Plasmodium falciparum rhoptry proteins to mouse erythrocytes and their possible role in invasion
13. Human erythrocyte ankyrin
14. Human malaria parasites in continuous culture
15. Cysteine protease inhibitors as chemotherapy for parasitic infections
16. Homology modeling of falcipain-2: Validation, de novo ligand design and synthesis of novel inhibitors